Muzia G I, Korobkova E N, Bergel'son L D
Biokhimiia. 1988 Apr;53(4):643-8.
Prostaglandin (PG) E1 was shown to stimulate the transfer of phosphatidylcholine and cholesterol esters from human high density lipoproteins to low density lipoproteins. The enhancement of the interlipoprotein lipid transfer by PGE1 was observed both at low prostaglandin concentrations under conditions of spontaneous exchange as well as in the presence of the lipoprotein-depleted plasma and the partly purified lipid transfer plasma protein. At the same time PGE2 showed no significant influence on the interlipoprotein lipid transfer. It is supposed that the effect of PGE1 is due to the PGE1-induced reorganization of the high density lipoprotein surface and that the PG-lipoprotein interaction is a factor which regulates cholesterol homeostasis.
前列腺素（PG）E1被证明可刺激磷脂酰胆碱和胆固醇酯从人高密度脂蛋白向低密度脂蛋白的转移。在自发交换条件下的低前列腺素浓度时，以及在缺乏脂蛋白的血浆和部分纯化的脂质转移血浆蛋白存在的情况下，均观察到PGE1增强了脂蛋白间的脂质转移。同时，PGE2对脂蛋白间的脂质转移没有显著影响。据推测，PGE1的作用是由于PGE1诱导的高密度脂蛋白表面的重组，并且PG-脂蛋白相互作用是调节胆固醇稳态的一个因素。
