Muzya G I, Korobkova E N, Golovanova N K, Bergelson L D
FEBS Lett. 1987 Aug 17;220(2):371-5. doi: 10.1016/0014-5793(87)80849-9.
Prostaglandin (PG) E1 was demonstrated to stimulate the transfer of phosphatidylcholine and cholesterol esters from human high density lipoproteins (HDL3) to low density lipoproteins (LDL). The enhancement effect of PGE1 on the interlipoprotein lipid transfer was seen at low PG concentrations under conditions of spontaneous exchange as well as in the presence of lipoprotein-depleted plasma, or partly purified plasma lipid exchange protein. PGE2 and PGF2 alpha showed no significant influence on the interlipoprotein lipid transfer. Evidence is presented suggesting that the PGE1-induced stimulation of interlipoprotein lipid exchange results in enhancement of LCAT-catalyzed cholesterol esterification in plasma. It is proposed that the effect of PGE1 is due to the previously described PGE1-induced reorganization of the HDL surface [(1984) FEBS Lett. 173, 291-293] and that PG-lipoprotein interaction may be a factor regulating cholesterol homeostasis.
前列腺素（PG）E1已被证明能刺激磷脂酰胆碱和胆固醇酯从人高密度脂蛋白（HDL3）向低密度脂蛋白（LDL）的转移。在自发交换条件下以及存在无脂蛋白血浆或部分纯化的血浆脂质交换蛋白的情况下，低浓度的PGE1就能观察到其对脂蛋白间脂质转移的增强作用。PGE2和PGF2α对脂蛋白间脂质转移无显著影响。有证据表明，PGE1诱导的脂蛋白间脂质交换刺激导致血浆中卵磷脂胆固醇酰基转移酶（LCAT）催化的胆固醇酯化增强。有人提出，PGE1的作用是由于先前描述的PGE1诱导的HDL表面重组[（1984年）《欧洲生物化学学会联合会快报》173，291 - 293]，并且PG - 脂蛋白相互作用可能是调节胆固醇稳态的一个因素。
