Graduate Program of Health Sciences and Technologies - PGCTS, University of Brasilia (UnB), Brasilia, Federal District, Brazil.
Federal Institute of Education, Science and Technology of Brasília, Brasilia, Federal District, Brazil.
Exp Gerontol. 2021 Jul 15;150:111389. doi: 10.1016/j.exger.2021.111389. Epub 2021 May 3.
To analyze the influence of inflammatory parameters and substitute insulin resistance indices on the risk of type 2 diabetes mellitus (DM) development in elderly women, as well as to compare anthropometric measures and metabolic parameters according to the presence of type 2 DM and HbA1c levels.
One hundred and twenty elderly women (67.9 ± 6.0 years) were submitted to anthropometric analysis, determination of inflammatory and metabolic parameters. They also underwent indices of lipid accumulation product (LAP), high density triglyceride/lipoprotein ratio (TG/HDL), triglyceride glucose index (TyG), as well as TyG by body mass index (BMI) ratio (TyG-BMI) assessment.
Body mass index, tumor necrosis factor alpha, interleukin-2, blood glucose, TG, LAP, TG/HDL, TyG and TyG-BMI were significantly higher in elderly women with DM compared to non-diabetic women. LAP ≥ 55.4 (OR = 2.29; P = .027); TyG ≥ 8.8 (OR = 3.52; P < .001) and TyG-BMI ≥ 264.8 (OR = 3.54; P = .001) were identified as risk factors for DM.
High pro-inflammatory parameters, low levels of anti-inflammatory markers and higher levels of substitute insulin resistance indices are risk predictors for DM development in elderly women in primary health care.
分析炎症参数和替代胰岛素抵抗指数对老年女性 2 型糖尿病（DM）发病风险的影响，并根据 2 型 DM 和 HbA1c 水平比较人体测量学指标和代谢参数。
120 名老年女性（67.9±6.0 岁）接受了人体测量分析、炎症和代谢参数的测定。她们还接受了脂堆积产物（LAP）、高密度甘油三酯/脂蛋白比（TG/HDL）、甘油三酯葡萄糖指数（TyG）以及体重指数（BMI）比值的 TyG（TyG-BMI）评估指数。
与非糖尿病女性相比，患有糖尿病的老年女性的体重指数、肿瘤坏死因子-α、白细胞介素-2、血糖、TG、LAP、TG/HDL、TyG 和 TyG-BMI 显著更高。LAP≥55.4（OR=2.29；P=.027）；TyG≥8.8（OR=3.52；P<.001）和 TyG-BMI≥264.8（OR=3.54；P=.001）被确定为 DM 的危险因素。
在初级保健中，高促炎参数、低抗炎标志物水平和更高的替代胰岛素抵抗指数是老年女性 DM 发病的风险预测因素。
