Department of Anesthesiology, Third Xiangya Hospital, Central South University, Changsha, China.
Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, China.
PLoS One. 2024 Nov 12;19(11):e0313488. doi: 10.1371/journal.pone.0313488. eCollection 2024.
To investigated the link between the systemic immunity-inflammation index (SII), a new inflammatory biomarker, and the risk of abnormal glucose regulation in non-diabetic population.
Using data from the 2005-2016 National Health and Nutrition Examination Survey (NHANES), we conducted a cross-sectional study on non-diabetic adults with data on SII and glucose regulation markers. We analyzed the relationship between SII and indicators of glucose regulation, including fasting plasma glucose, fasting insulin, hemoglobin A1c, oral glucose tolerance test (OGTT), and states of abnormal glucose regulation like impaired glucose tolerance (IGT), insulin resistance, and prediabetes.
Adjusting for confounders, higher SII levels were significantly associated with a higher OGTT and a greater likelihood of IGT (OR = 2.673, 95% CI: 1.845, 3.873). In subgroup analysis, participants without hyperlipidemia in the highest SII quartile had a 240% higher odds of IGT compared to those in the lowest quartile (OR = 3.407, 95%CI: 1.995, 5.820), an association not observed in those with hyperlipidemia (p for interaction < 0.05).
SII emerges as a useful biomarker for identifying IGT in non-diabetic individuals, specifically in those without hyperlipidemia.
本研究旨在探讨系统性免疫炎症指数（SII）这一新型炎症标志物与非糖尿病患者糖调节异常风险之间的关联。
本研究利用 2005-2016 年全国健康与营养调查（NHANES）的数据，对具有 SII 和血糖调节标志物数据的非糖尿病成年人进行了横断面研究。我们分析了 SII 与血糖调节指标之间的关系，包括空腹血糖、空腹胰岛素、糖化血红蛋白、口服葡萄糖耐量试验（OGTT）以及异常血糖调节状态，如糖耐量受损（IGT）、胰岛素抵抗和糖尿病前期。
校正混杂因素后，较高的 SII 水平与更高的 OGTT 和更大的 IGT 发生风险显著相关（OR=2.673，95%CI：1.845，3.873）。在亚组分析中，与最低四分位数相比，最高四分位数中无高脂血症的参与者发生 IGT 的几率高出 240%（OR=3.407，95%CI：1.995，5.820），而在高脂血症患者中则无此关联（p 交互<0.05）。
SII 可作为识别非糖尿病个体 IGT 的有用生物标志物，尤其适用于无高脂血症的个体。
