雪貂气管体外黏液流速、放射性标记糖蛋白输出及平滑肌收缩的比较
Comparison of mucus flow rate, radiolabelled glycoprotein output and smooth muscle contraction in the ferret trachea in vitro.
作者信息
Kyle H, Widdicombe J G, Wilffert B
机构信息
Department of Physiology, St. George's Hospital Medical School, London.
出版信息
Br J Pharmacol. 1988 Jun;94(2):293-8. doi: 10.1111/j.1476-5381.1988.tb11530.x.
Abstract
- The concentration-response curves for rate of mucus output, labelled-glycoprotein output and smooth muscle contraction in response to methacholine, phenylephrine and salbutamol were determined in the ferret trachea in vitro. 2. The potencies of methacholine and phenylephrine are both in order: smooth muscle contraction, glycoprotein output, rate of mucus output. 3. At lower concentrations methacholine is more potent than is phenylephrine on smooth muscle contraction, glycoprotein output and rate of mucus output. 4. Concentration-response curves for salbutamol show very little change in rate of mucus output but a large increase in glycoprotein output. 5. It is concluded that the glycoprotein output induced by salbutamol may come from a source different from those induced by methacholine and phenylephrine.
摘要
- 在体外测定雪貂气管对乙酰甲胆碱、去氧肾上腺素和沙丁胺醇反应的黏液分泌速率、标记糖蛋白分泌及平滑肌收缩的浓度-反应曲线。2. 乙酰甲胆碱和去氧肾上腺素的效力顺序均为：平滑肌收缩、糖蛋白分泌、黏液分泌速率。3. 在较低浓度时，乙酰甲胆碱对平滑肌收缩、糖蛋白分泌和黏液分泌速率的作用比去氧肾上腺素更强。4. 沙丁胺醇的浓度-反应曲线显示黏液分泌速率变化很小，但糖蛋白分泌大幅增加。5. 得出的结论是，沙丁胺醇诱导的糖蛋白分泌可能来自与乙酰甲胆碱和去氧肾上腺素诱导的不同来源。
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