肽组氨酸异亮氨酸和神经肽Y对雪貂气管黏液分泌量的影响。
The effects of peptide histidine isoleucine and neuropeptide Y on mucus volume output from the ferret trachea.
作者信息
Webber S E
机构信息
Department of Physiology, St George's Hospital Medical School, London.
出版信息
Br J Pharmacol. 1988 Sep;95(1):49-54. doi: 10.1111/j.1476-5381.1988.tb16547.x.
Abstract
- The effects of peptide histidine isoleucine (PHI) and neuropeptide Y (NPY) were examined on the mucus volume output produced by methacholine and phenylephrine in the ferret whole trachea in vitro. 2. Sustained application of methacholine (5 microM) or phenylephrine (20 microM) produced a maintained volume output of mucus from the trachea. Both these agonists also increased the output of lysozyme (a marker for serous cell secretion). 3. PHI inhibited the maintained mucus volume output produced by methacholine but had no effect on that due to phenylephrine. The output of lysozyme produced by methacholine or phenylephrine was not significantly changed by PHI. 4. NPY enhanced the volume output of mucus produced by methacholine or phenylephrine; however, the rate of output of lysozyme in mucus produced by both agonists was reduced by NPY. 5. We suggest that PHI has no effect on serous cell secretion but inhibits secretion from another source, possibly mucous cells. NPY inhibits serous cell secretion but has a stronger stimulant action on secretion from another source, again possibly mucous cells. 6. PHI and NPY may be important physiological modulators of mucus volume output in the ferret trachea.
摘要
- 研究了肽组氨酸异亮氨酸（PHI）和神经肽Y（NPY）对雪貂离体全气管中由乙酰甲胆碱和去氧肾上腺素产生的黏液量输出的影响。2. 持续应用乙酰甲胆碱（5微摩尔）或去氧肾上腺素（20微摩尔）可使气管产生持续的黏液量输出。这两种激动剂还增加了溶菌酶（浆液细胞分泌的标志物）的输出。3. PHI抑制了乙酰甲胆碱产生的持续黏液量输出，但对去氧肾上腺素所致的黏液量输出无影响。PHI对乙酰甲胆碱或去氧肾上腺素产生的溶菌酶输出无显著影响。4. NPY增强了乙酰甲胆碱或去氧肾上腺素产生的黏液量输出；然而，NPY降低了两种激动剂产生的黏液中溶菌酶的输出速率。5. 我们认为，PHI对浆液细胞分泌无影响，但抑制来自其他来源（可能是黏液细胞）的分泌。NPY抑制浆液细胞分泌，但对来自其他来源（同样可能是黏液细胞）的分泌具有更强的刺激作用。6. PHI和NPY可能是雪貂气管中黏液量输出的重要生理调节因子。
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