Maugeri Andrea, Barchitta Martina, Magnano San Lio Roberta, Scalisi Aurora, Agodi Antonella
Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, Via Santa Sofia 87, 95123Catania, Italy.
Cervical Cancer Screening Unit, Azienda Sanitaria Provinciale of Catania, Catania, Italy.
Public Health Nutr. 2022 Jun;25(6):1577-1585. doi: 10.1017/S1368980021001944. Epub 2021 May 7.
To evaluate the association of Composite Dietary Antioxidant Index (CDAI) and Dietary Inflammatory Index (DII) with the prevalence of high-grade cervical intraepithelial neoplasia (CIN).
A cross-sectional study was conducted on women with abnormal Papanicolaou test, who underwent high-risk human papillomavirus (HPV) screening and histological test through colposcopy. Dietary data were collected using a FFQ and used to assess both CDAI and DII.
Women were recruited from 2012 to 2015 at the Cervical Cancer Screening Unit of the 'Azienda Sanitaria Provinciale' of Catania (Italy).
The study included 539 women with a mean age of 40·2 years, who were classified as cases (n 127 with CIN2 or more severe lesions) and controls (n 412 with normal cervical epithelium or CIN1).
Although we observed a lower proportion of HPV-positive women among those with higher CDAI (P < 0·001), the index was not associated with the diagnosis of CIN2 or more severe lesions. By contrast, women with medium or high DII showed higher odds to be diagnosed with CIN2 or more severe lesions than those with low DII (OR = 2·15; 95 % CI 1·11, 4·17; P = 0·024 and OR = 3·14; 95 % CI 1·50, 6·56; P = 0·002, respectively), after adjusting for age, HPV status, educational level, BMI, smoking status, parity, use of oral contraceptives and supplements.
Our findings suggested that a pro-inflammatory diet might be associated with an increased risk of CIN2 and more severe lesions. However, further prospective studies should be encouraged to support this evidence.
评估复合膳食抗氧化指数（CDAI）和膳食炎症指数（DII）与高级别宫颈上皮内瘤变（CIN）患病率之间的关联。
对巴氏试验异常的女性进行横断面研究，这些女性通过阴道镜检查接受了高危型人乳头瘤病毒（HPV）筛查和组织学检查。使用食物频率问卷收集膳食数据，并用于评估CDAI和DII。
2012年至2015年期间，从意大利卡塔尼亚“省级卫生机构”的宫颈癌筛查单位招募女性。
该研究纳入了539名平均年龄为40.2岁的女性，她们被分为病例组（127例CIN2或更严重病变）和对照组（412例宫颈上皮正常或CIN1）。
尽管我们观察到CDAI较高的女性中HPV阳性的比例较低（P<0.001），但该指数与CIN2或更严重病变的诊断无关。相比之下，在调整年龄、HPV状态、教育水平、体重指数、吸烟状况、生育情况、口服避孕药和补充剂的使用后，DII中等或高的女性被诊断为CIN2或更严重病变的几率高于DII低的女性（OR=2.15；95%CI 1.11，4.17；P=0.024和OR=3.14；95%CI 1.50，6.56；P=0.002）。
我们的研究结果表明，促炎性饮食可能与CIN2及更严重病变的风险增加有关。然而，应鼓励进一步的前瞻性研究来支持这一证据。
