Ding Yingchao, Fan Miaomiao, Jiang Chen, Dou Naixin, Guo Yaqi, Zhao Xiaolin, Sun Xin, Yu Chunxiao, Guan Qingbo
Department of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, China.
Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China.
Int J Endocrinol. 2025 Apr 18;2025:3255533. doi: 10.1155/ije/3255533. eCollection 2025.
Evidence regarding the associations of composite dietary antioxidant index (CDAI) with the risk of prevalence and mortality of nonalcoholic fatty liver disease (NAFLD) is limited. We aimed to investigate these relationships using data from the National Health and Nutrition Examination Survey (NHANES). A total of 19,404 individuals with a mean age of 50.10 years were included. In multivariate-adjusted logistic regression analysis, compared to those in the lowest quartile of CDAI, individuals with the highest quartile were negatively associated with NAFLD prevalence (OR: 0.85, 95% CI: 0.75, 0.96), and the dose-response curve exhibited a linear relationship. Moreover, multivariate-adjusted Cox regression revealed that individuals with the highest quartile were negatively associated with cancer mortality (HR: 0.61, 95% CI: 0.37, 0.99) compared to those with the lowest quartile of CDAI in NAFLD patients. Moreover, the dose-response analysis demonstrated that CDAI had a nonlinear association with all-cause mortality in NAFLD patients. Multiple stratified and sensitivity analyses demonstrated that these associations are stable. CDAI was protective against the prevalence and cancer mortality of NAFLD. These results may provide new insights into adapting CDAI as a dietary strategy to prevent and improve the prognosis of NAFLD.
关于复合膳食抗氧化指数（CDAI）与非酒精性脂肪性肝病（NAFLD）患病率及死亡率之间关联的证据有限。我们旨在利用美国国家健康与营养检查调查（NHANES）的数据来研究这些关系。总共纳入了19404名平均年龄为50.10岁的个体。在多变量调整的逻辑回归分析中，与CDAI最低四分位数组的个体相比，最高四分位数组的个体与NAFLD患病率呈负相关（比值比：0.85，95%置信区间：0.75，0.96），且剂量反应曲线呈线性关系。此外，多变量调整的Cox回归显示，在NAFLD患者中，与CDAI最低四分位数组的个体相比，最高四分位数组的个体与癌症死亡率呈负相关（风险比：0.61，95%置信区间：0.37，0.99）。而且，剂量反应分析表明，CDAI与NAFLD患者的全因死亡率呈非线性关联。多项分层和敏感性分析表明这些关联是稳定的。CDAI对NAFLD的患病率和癌症死亡率具有保护作用。这些结果可能为将CDAI作为一种饮食策略来预防和改善NAFLD的预后提供新的见解。
