Hong Kai, Leidner Andrew J, Tsai Yuping, Tang Zhaoli, Cho Bo-Hyun, Stokley Shannon
Immunization Service Division, National Center for Immunization and Respiratory Diseases (NCIRD) (K Hong, AJ Leidner, Y Tsai, B-H Cho, and S Stokley), Centers for Disease Control and Prevention (CDC), Atlanta, Ga.
Immunization Service Division, National Center for Immunization and Respiratory Diseases (NCIRD) (K Hong, AJ Leidner, Y Tsai, B-H Cho, and S Stokley), Centers for Disease Control and Prevention (CDC), Atlanta, Ga.
Acad Pediatr. 2021 May-Jun;21(4S):S67-S77. doi: 10.1016/j.acap.2020.11.015.
The Community Preventive Services Task Force (CPSTF) has recommended several interventions that have been demonstrated to be effective at increasing vaccination coverage.
Conduct a systematic review to examine the costs of interventions designed to increase vaccination coverage among children and adolescents in the United States.
PubMed, EconLit, Embase, and Cochrane.
STUDY ELIGIBILITY, PARTICIPANTS, AND INTERVENTIONS: Peer-reviewed articles from January 1, 2009 to August 31, 2019.
Studies were identified with systematic searches of the literature, reviewed for inclusion criteria, abstracted for data on intervention, target population, costs, and risk of bias. Cost measures were reported as costs per child in the target population, costs per vaccinated child, incremental costs per vaccinated child, and costs per vaccine dose administered. Results were stratified by intervention type, vaccine, and age group.
Thirty-seven studies were identified for full-text review. Across all interventions and age groups, the cost per child ranged from $0.10 to $537.38, and the incremental cost per vaccinated child ranged from $6.52 to $5,098.57. Provider assessment and feedback interventions had the lowest (median) cost per child ($0.17) and a healthcare system-based combined intervention with multiple components had the lowest (median) incremental cost per vaccinated child ($26.65). A community-based combined intervention with multiple components had the highest median cost per child ($537.38) and the highest median incremental cost per vaccinated child ($5,098.57).
A small number of included intervention types and inconsistent cost definition.
There is substantial variability in the costs of CPSTF-recommended interventions.
社区预防服务工作组（CPSTF）推荐了几种已被证明能有效提高疫苗接种覆盖率的干预措施。
进行一项系统评价，以研究旨在提高美国儿童和青少年疫苗接种覆盖率的干预措施的成本。
PubMed、EconLit、Embase和Cochrane。
研究资格、参与者和干预措施：2009年1月1日至2019年8月31日期间的同行评审文章。
通过系统检索文献来识别研究，根据纳入标准进行评审，提取关于干预措施、目标人群、成本和偏倚风险的数据。成本指标报告为目标人群中每个儿童的成本、每个接种疫苗儿童的成本、每个接种疫苗儿童的增量成本以及每剂疫苗接种的成本。结果按干预类型、疫苗和年龄组进行分层。
确定了37项研究进行全文评审。在所有干预措施和年龄组中，每个儿童的成本从0.10美元到537.38美元不等，每个接种疫苗儿童的增量成本从6.52美元到5098.57美元不等。提供者评估和反馈干预措施的每个儿童（中位数）成本最低（0.17美元），基于医疗保健系统的多成分联合干预措施的每个接种疫苗儿童（中位数）增量成本最低（26.65美元）。基于社区的多成分联合干预措施的每个儿童中位数成本最高（537.38美元），每个接种疫苗儿童的中位数增量成本最高（5098.57美元）。
纳入的干预类型数量较少且成本定义不一致。
CPSTF推荐的干预措施成本存在很大差异。
