Vanderwolf C H, Stewart D J
Department of Psychology, University of Western Ontario, London, Canada.
Brain Res Bull. 1988 Apr;20(4):529-38. doi: 10.1016/0361-9230(88)90143-8.
Bilateral intrathalamic injection of kainic acid in rats produces widespread destruction of thalamic neurons but does not abolish neocortical activation (generation of low voltage fast activity, LVFA). On the other hand, a combination of reserpine and scopolamine abolishes all LVFA but does not abolish thalamocortical transmission as assessed by recruiting responses, augmenting responses, and sensory evoked neocortical potentials. These facts show that thalamocortical transmission is neither necessary nor sufficient to produce neocortical activation. The classical view of neocortical activation as dependent on a reticulothalamocortical pathway seems to be incorrect. It appears, instead, that neocortical activation is dependent jointly on a cholinergic input from the basal forebrain and a serotonergic input from the brainstem.
向大鼠双侧丘脑内注射海藻酸会导致丘脑神经元广泛受损，但不会消除新皮层激活（产生低电压快速活动，LVFA）。另一方面，利血平和东莨菪碱联合使用可消除所有LVFA，但通过募集反应、增强反应和感觉诱发新皮层电位评估，并不会消除丘脑皮质传递。这些事实表明，丘脑皮质传递对于产生新皮层激活既非必要条件也非充分条件。关于新皮层激活依赖于网状丘脑皮质通路的经典观点似乎是不正确的。相反，新皮层激活似乎共同依赖于来自基底前脑的胆碱能输入和来自脑干的5-羟色胺能输入。
