Avilala Janardhan, Becnel David, Abdelghani Ramsy, Nanbo Asuka, Kahn Jacob, Li Li, Lin Zhen
Tulane University Health Sciences Center and Tulane Cancer Center, New Orleans, LA, United States.
Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, United States.
Front Microbiol. 2021 Apr 20;12:657036. doi: 10.3389/fmicb.2021.657036. eCollection 2021.
Human oncogenic viruses are a group of important pathogens that etiologically contribute to at least 12% of total cancer cases in the world. As an emerging class of non-linear regulatory RNA molecules, circular RNAs (circRNAs) have gained increasing attention as a crucial player in the regulation of signaling pathways involved in viral infection and oncogenesis. With the assistance of current circRNA enrichment and detection technologies, numerous novel virally-encoded circRNAs (vcircRNAs) have been identified in the human oncogenic viruses, initiating an exciting new era of vcircRNA research. In this review, we discuss the current understanding of the roles of vcircRNAs in the respective viral infection cycles and in virus-associated pathogenesis.
人类致癌病毒是一类重要的病原体，在全球所有癌症病例中，其病因学贡献率至少为12%。作为一类新兴的非线性调控RNA分子，环状RNA（circRNA）作为病毒感染和肿瘤发生相关信号通路调控中的关键参与者，受到了越来越多的关注。借助当前的circRNA富集和检测技术，在人类致癌病毒中已鉴定出大量新的病毒编码环状RNA（vcircRNA），开启了vcircRNA研究的一个令人兴奋的新时代。在本综述中，我们讨论了目前对vcircRNA在各自病毒感染周期及病毒相关发病机制中作用的理解。
