Starch-Jensen Thomas, Deluiz Daniel, Vitenson Julie, Bruun Niels Henrik, Tinoco Eduardo Muniz Barretto
Department of Oral and Maxillofacial Surgery, Aalborg University Hospital, AalborgDenmark.
Department of Periodontology, Rio de Janeiro State University, Rio de JaneiroBrazil.
J Oral Maxillofac Res. 2021 Mar 31;12(1):e1. doi: 10.5037/jomr.2021.12101. eCollection 2021 Jan-Mar.
Test the hypothesis of no difference in the volumetric stability of the grafting material following maxillary sinus floor augmentation with autogenous bone graft compared with composite grafting material or bone substitute alone applying the lateral window technique.
MEDLINE (PubMed), Embase, Cochrane library and hand-search of relevant journals were conducted. Human studies published in English until the 9 of October 2020 were included. Outcome measures included three-dimensional volumetric changes of the grafting material and potential predictive parameters. Volumetric changes were evaluated by descriptive statistics and meta-analysis including 95% confidence interval.
Electronic search and hand-searching resulted in 102 entries. Four randomized controlled trials with unclear risk of bias fulfilled the inclusion criteria. The volumetric stability of the grafting material was significantly improved by mixing autogenous bone graft with a non-resorbable xenograft compared with autogenous bone graft. Meta-analyses assessing absolute and relative volumetric changes demonstrated no significant differences between autogenous bone graft compared with allogeneic bone graft, synthetic biomaterials combined with autogenous bone graft or used alone. Association between volumetric changes of the grafting material and potential predictive parameters were not assessed in the included studies.
Volumetric reduction of the augmented area seems inevitable following maxillary sinus floor augmentation regardless of the grafting material. The volumetric stability of autogenous bone graft is improved with addition of xenograft compared with autogenous bone graft. However, conclusions drawn from this systematic review should be interpreted with caution since only four studies using three-dimensional radiographic measurements were included.
检验在上颌窦底提升术中，采用外侧开窗技术时，自体骨移植与复合移植材料或单独使用骨替代物相比，移植材料的体积稳定性无差异这一假设。
检索了MEDLINE（PubMed）、Embase、Cochrane图书馆，并对相关期刊进行了手工检索。纳入截至2020年10月9日发表的英文人体研究。观察指标包括移植材料的三维体积变化和潜在的预测参数。通过描述性统计和包括95%置信区间的荟萃分析来评估体积变化。
电子检索和手工检索共得到102条记录。四项偏倚风险不明确的随机对照试验符合纳入标准。与自体骨移植相比，自体骨移植与不可吸收异种移植混合使用可显著提高移植材料的体积稳定性。评估绝对和相对体积变化的荟萃分析表明，自体骨移植与同种异体骨移植、自体骨移植联合合成生物材料或单独使用合成生物材料之间无显著差异。纳入研究未评估移植材料体积变化与潜在预测参数之间的关联。
无论使用何种移植材料，上颌窦底提升术后植骨区体积缩小似乎是不可避免的。与自体骨移植相比，添加异种移植可提高自体骨移植的体积稳定性。然而，由于仅纳入了四项使用三维放射学测量的研究，本系统评价得出的结论应谨慎解读。
