Division of Clinical Research & Technological Development, Brazilian National Cancer Institute (INCA), André Cavalcanti St, 37, 5th floor Centro, Rio de Janeiro, 20231-050, Brazil.
Future Oncol. 2021 Aug;17(22):2857-2865. doi: 10.2217/fon-2020-1313. Epub 2021 May 7.
The current study aims to present epidemiologic changes and clinical aspects of Merkel cell carcinoma (MCC) in Brazil. Data were collected from the Brazilian Population-Based Cancer Registries (2000-2015) and Hospital-Based Cancer Registries (2000-2017). The average age-standardized incidence rates significantly increased in men between the years 2000 (0.31/1,000,000) and 2015 (1.21/1,000,000), with an annual percentage change of 9.4 (95% CI: 4.7-14.4; p < 0.001). In women, the incidence rates rose insignificantly in the period with an annual percentage change of 3.1 (95% CI: 0.0-6.2; p < 0.10). From the hospital-based database, 881 MCC patients were identified. Most of the patients were females (51.2%), aged >60 years (82.2%), White (67.6%) and diagnosed at stages III or IV (50.5%). A key aspect of public health promotion is to understand the incidence and morbidity of MCC.
本研究旨在介绍巴西 Merkel 细胞癌（MCC）的流行病学变化和临床特征。数据来自巴西基于人群的癌症登记处（2000-2015 年）和基于医院的癌症登记处（2000-2017 年）。2000 年至 2015 年期间，男性年龄标准化发病率显著上升，从 0.31/100 万上升至 1.21/100 万，年变化百分比为 9.4%（95%CI：4.7-14.4；p<0.001）。女性发病率在这一期间略有上升，年变化百分比为 3.1%（95%CI：0.0-6.2；p<0.10）。从基于医院的数据库中，确定了 881 例 MCC 患者。大多数患者为女性（51.2%），年龄>60 岁（82.2%），为白人（67.6%），且处于 III 期或 IV 期（50.5%）。促进公共卫生的一个关键方面是了解 MCC 的发病率和发病情况。
