Center of Clinical Epidemiology, c/o Institute of Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Hufelandstr. 55, 45147 Essen, Germany; School of Public Health, Department of Epidemiology, Boston University, 715 Albany Street, Talbot Building, Boston, MA 02118, USA; German Consortium for Translational Cancer Research (DKTK), Partner Site University Hospital of Essen, Hufelandstr. 55, 45147 Essen, Germany.
German Consortium for Translational Cancer Research (DKTK), Partner Site University Hospital of Essen, Hufelandstr. 55, 45147 Essen, Germany; Department Translational Skin Cancer Research (TSCR), University Hospital of Essen, University of Duisburg-Essen, 45114 Essen, Germany.
Eur J Cancer. 2018 May;94:47-60. doi: 10.1016/j.ejca.2018.02.003. Epub 2018 Mar 20.
The aim of this article was to provide worldwide, population-based incidence rates for Merkel cell carcinoma (MCC).
We included 11,576 cases from 20 countries for time trend analyses (1990-2007) and 11,028 cases (2.5 billion person-years) from 21 countries for the period 2003-2007 extracted from Cancer Incidence in Five Continents. We computed age-standardised incidence rates (World Standard population) per million person years and sex ratios of these rates. We estimated annual percentage changes (EAPCs) of the incidence and studied the association between geographic latitude and MCC incidence. We examined the body site distribution of MCC.
In the majority of populations, the incidence has increased over time (EAPC, men 2.0-21.0%; women 1.6-27.2%). Rate differences between 1995 and 2007 were typically small (men: 0.8-2.2; women: 0.2-1.7). The incidence was relatively stable in some populations (men: U.S. blacks, Japan, Norway, Denmark; women: Denmark, Norway, Sweden). Incidences from 2003 to 2007 were highest in Australia, New Zealand, the United States and Israel among men and in New Zealand, Australia, Ireland and the Netherlands among women. The incidence of MCC and melanoma among white non-Hispanic males in North America was positively associated with living closer to the equator. The proportion of MCC on the head was higher with advanced age. The head was a less likely primary site among blacks as compared with any other ethnicity.
Several countries showed increases in MCC incidence among white non-Hispanics over time. Latitude closer to the equator was associated with the MCC incidence in North American men, but barely in women, possibly due to occupational sunlight exposure patterns.
本文旨在提供全球范围内基于人群的 Merkel 细胞癌（MCC）发病率数据。
我们纳入了来自 20 个国家的 11576 例病例用于时间趋势分析（1990-2007 年），并从《五大洲癌症发病率》中提取了来自 21 个国家的 11028 例病例（25 亿人年）用于 2003-2007 年期间的分析。我们计算了每百万人口年的年龄标准化发病率（世界标准人口）和这些发病率的性别比。我们估计了发病率的年百分变化（EAPC），并研究了地理纬度与 MCC 发病率之间的关系。我们检查了 MCC 的身体部位分布。
在大多数人群中，发病率随时间呈上升趋势（EAPC，男性为 2.0-21.0%；女性为 1.6-27.2%）。1995 年和 2007 年之间的发病率差异通常较小（男性：0.8-2.2；女性：0.2-1.7）。在一些人群中，发病率相对稳定（男性：美国黑人、日本、挪威、丹麦；女性：丹麦、挪威、瑞典）。2003 年至 2007 年期间，男性发病率最高的是澳大利亚、新西兰、美国和以色列，女性发病率最高的是新西兰、澳大利亚、爱尔兰和荷兰。北美的白人非西班牙裔男性中，MCC 和黑色素瘤的发病率与靠近赤道的距离呈正相关。随着年龄的增长，MCC 发生在头部的比例更高。与其他任何种族相比，黑人的 MCC 更不可能发生在头部。
一些国家的白人非西班牙裔人群中 MCC 发病率随时间呈上升趋势。靠近赤道的纬度与北美的男性 MCC 发病率相关，但在女性中几乎没有相关性，这可能是由于职业性日光暴露模式的原因。
