Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Beijing Institute of Ophthalmology, Beijing, China.
Acta Ophthalmol. 2022 Feb;100(1):e253-e261. doi: 10.1111/aos.14887. Epub 2021 May 7.
To investigate the development of angle closure from baseline open angle and associated risk factors in a rural Chinese population through a longitudinal study over a 5-year period.
Subjects aged ≥30 years and older with bilateral open angles at baseline of the Handan Eye Study who participated in the follow-up and had undergone both baseline and follow-up gonioscopic examinations were included. Subjects with any form of angle closure, glaucoma, incisional ocular surgery or other conditions that could influence the results were excluded. The development of angle closure was defined as the presence of primary angle closure suspect (PACS) or primary angle closure (PAC)/primary angle closure glaucoma (PACG) during the follow-up in normal subjects with baseline bilateral open angles. Logistic regression was performed to identify the baseline risk factors for the development of angle closure.
A total of 457 subjects with bilateral open angles at baseline aged 53.0 (45.5, 58.0) years were enrolled. 94.7% of the included cases developed PACS, 5.3% developed PAC and no one developed PACG after 5 years. In logistic regression, significant risk factors for the development of angle closure were shallower central anterior chamber depth (ACD) (p = 0.002) and narrower mean angle width (p < 0.001).
This study reports the development from baseline open angle to angle closure after a 5-year follow-up. We confirm that the mean angle width and central ACD were independent predictive risk factors for the development of any form of angle closure.
通过一项为期 5 年的纵向研究，调查中国农村人群中从基线开放性眼角度发展为闭角型青光眼的情况及其相关危险因素。
本研究纳入了基线时双侧为开放性眼角度的韩丹眼部研究中的年龄≥30 岁的受试者，这些受试者参加了随访，并接受了基线和随访时的房角镜检查。排除了任何形式的闭角型青光眼、青光眼、切口性眼部手术或其他可能影响结果的情况。在基线时双侧为开放性眼角度的正常受试者中，将随访期间出现原发性闭角型青光眼可疑（PACS）或原发性闭角型青光眼（PAC）/原发性闭角型青光眼（PACG）定义为闭角型青光眼的发展。采用逻辑回归分析确定闭角型青光眼发展的基线危险因素。
共纳入了 457 例基线时双侧为开放性眼角度的受试者，年龄为 53.0（45.5，58.0）岁。94.7%的纳入病例出现了 PACS，5.3%出现了 PAC，5 年后没有人出现 PACG。逻辑回归分析显示，闭角型青光眼发展的显著危险因素为中央前房深度（ACD）较浅（p=0.002）和平均房角宽度较窄（p<0.001）。
本研究报告了在 5 年随访后从基线开放性眼角度发展为闭角型青光眼的情况。我们证实平均房角宽度和中央 ACD 是任何形式的闭角型青光眼发展的独立预测危险因素。
