窄带成像结肠镜下评估黏膜血管模式预测溃疡性结肠炎黏膜增殖。
Predicting Mucosal Proliferation in Ulcerative Colitis by Assessing Mucosal Vascular Pattern Under Narrow Band Imaging Colonoscopy.
机构信息
Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
出版信息
Turk J Gastroenterol. 2021 Feb;32(2):203-208. doi: 10.5152/tjg.2021.20256.
BACKGROUND
Proliferative abnormalities are believed to represent an early phase of colorectal carcinogenesis. Narrow band imaging (NBI) colonoscopy allows visual assessment of the mucosal vascular pattern (MVP) without dyeing. The aim of this study was to investigate the predictive value of MVP for mucosal proliferation in ulcerative colitis (UC).
METHODS
A total of 119 colorectal lesions were analyzed from 42 patients with UC who underwent NBI colonoscopy. Both the MVP and the Mayo endoscopic score (MES) were assessed. The mucosal inflammation was histologically graded using a colitis score. The proliferation marker Ki-67 was assessed by immunohistochemical staining.
RESULTS
The results showed that MVP correlated well with the MES (r = 0.796, P < .001). There was moderate correlation between the distribution of Ki-67 staining and MVP (r = 0.492, P < .001), and the Ki-67 labeling index increased with the orderly patterns of MVP (P < .001). An expansion of Ki-67 staining upward from the crypt base may be caused by active inflammation.
CONCLUSION
MVP based on NBI colonoscopy can predict mucosal proliferation which is associated with inflammation in patients with UC.
背景
增生异常被认为代表结直肠癌变的早期阶段。窄带成像（NBI）结肠镜检查允许在不染色的情况下观察黏膜血管模式（MVP）。本研究旨在探讨 MVP 对溃疡性结肠炎（UC）黏膜增生的预测价值。
方法
对 42 例接受 NBI 结肠镜检查的 UC 患者的 119 个结直肠病变进行了分析。评估 MVP 和 Mayo 内镜评分（MES）。使用结肠炎评分对黏膜炎症进行组织学分级。通过免疫组织化学染色评估增殖标志物 Ki-67。
结果
结果表明 MVP 与 MES 相关性良好（r = 0.796，P <.001）。Ki-67 染色的分布与 MVP 之间存在中度相关性（r = 0.492，P <.001），Ki-67 标记指数随着 MVP 的有序模式增加（P <.001）。从隐窝基底向上扩展的 Ki-67 染色可能是由活跃的炎症引起的。
结论
基于 NBI 结肠镜检查的 MVP 可以预测与 UC 患者炎症相关的黏膜增生。
Zotero 插件