原肌球蛋白-1 在心血管疾病中的作用。
The role of profilin-1 in cardiovascular diseases.
机构信息
Bioengineering, University of Pittsburgh.
Pathology, University of Pittsburgh, 306 Center for Bioengineering, University of Pittsburgh, 300 Technology Drive, Pittsburgh, PA 15219, USA.
出版信息
J Cell Sci. 2021 May 1;134(9). doi: 10.1242/jcs.249060. Epub 2021 May 7.
Abstract
Dynamic remodeling of the actin cytoskeleton is an essential feature for virtually all actin-dependent cellular processes, including cell migration, cell cycle progression, chromatin remodeling and gene expression, and even the DNA damage response. An altered actin cytoskeleton is a structural hallmark associated with numerous pathologies ranging from cardiovascular diseases to immune disorders, neurological diseases and cancer. The actin cytoskeleton in cells is regulated through the orchestrated actions of a myriad of actin-binding proteins. In this Review, we provide a brief overview of the structure and functions of the actin-monomer-binding protein profilin-1 (Pfn1) and then discuss how dysregulated expression of Pfn1 contributes to diseases associated with the cardiovascular system.
摘要
肌动蛋白细胞骨架的动态重塑是几乎所有依赖肌动蛋白的细胞过程的一个基本特征，包括细胞迁移、细胞周期进程、染色质重塑和基因表达，甚至是 DNA 损伤反应。改变的肌动蛋白细胞骨架是与许多病理学相关的结构标志，从心血管疾病到免疫紊乱、神经疾病和癌症。细胞中的肌动蛋白细胞骨架通过无数肌动蛋白结合蛋白的协调作用进行调节。在这篇综述中，我们简要概述了肌动蛋白单体结合蛋白 Profilin-1（Pfn1）的结构和功能，然后讨论了 Pfn1 表达失调如何导致与心血管系统相关的疾病。
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