ecDNA 豪华派对大巴：让增强子来到你身边。
ecDNA party bus: Bringing the enhancer to you.
机构信息
Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Mol Cell. 2021 May 6;81(9):1866-1867. doi: 10.1016/j.molcel.2021.04.017.
PMID:33961776
Abstract
Recent work from Zhu et al. (2021) reveals that extrachromosomal DNA circles harboring enhancers can serve as mobile regulatory elements that interact with chromosomal oncogenes, stimulating high-level gene activity and contributing to tumor heterogeneity and cancer progression.
摘要
最近，Zhu 等人（2021）的研究揭示了含有增强子的染色体外 DNA 环可以作为可移动的调节元件，与染色体癌基因相互作用，刺激高水平的基因活性，并导致肿瘤异质性和癌症进展。
Zotero 插件