Department of Rheumatology and Immunology, the First Affiliated Hospital of USTC, China; Division of Life Sciences and Medicine, University of Science and Technology of China, No. 17 LuJiang Road, Hefei 230001, Anhui, China.
Department of Rheumatology and Immunology, the First Affiliated Hospital of USTC, China; Division of Life Sciences and Medicine, University of Science and Technology of China, No. 17 LuJiang Road, Hefei 230001, Anhui, China.
Life Sci. 2021 Aug 1;278:119579. doi: 10.1016/j.lfs.2021.119579. Epub 2021 May 5.
Hyperlipidemia, an independent risk factor for atherosclerosis, is regarded as a lipid metabolism disorder associated with elevated plasma triglyceride and/or cholesterol. Genetic factors and unhealthy lifestyles, such as excess caloric intake and physical inactivity, can result in hyperlipidemia. Taurine, a sulfur-containing non-essential amino acid, is abundant in marine foods and has been associated with wide-ranging beneficial physiological effects, with special reference to regulating aberrant lipid metabolism. Its anti-hyperlipidemic mechanism is complex, which is related to many enzymes in the process of fat anabolism and catabolism (e.g., HMGCR, CYP7A1, LDLR, FXR, FAS and ACC). Anti-inflammatory and antioxidant molecular targets, lipid autophagy, metabolic reprogramming and gut microbiota will also be reviewed.
高脂血症是动脉粥样硬化的独立危险因素，被认为是一种与血浆甘油三酯和/或胆固醇升高有关的脂质代谢紊乱。遗传因素和不健康的生活方式，如摄入过多的热量和缺乏身体活动，都可能导致高脂血症。牛磺酸是一种含硫的非必需氨基酸，在海洋食品中含量丰富，与广泛的有益生理效应有关，特别是与调节异常的脂质代谢有关。其抗高脂血症的机制很复杂，与脂肪合成和分解过程中的许多酶有关（如 HMGCR、CYP7A1、LDLR、FXR、FAS 和 ACC）。抗炎和抗氧化的分子靶点、脂自噬、代谢重编程和肠道微生物群也将进行综述。
