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壳寡糖片对高脂饮食诱导的高血脂大鼠血脂的影响

Therapeutic Effect of Chitooligosaccharide Tablets on Lipids in High-Fat Diets Induced Hyperlipidemic Rats.

机构信息

Guangdong Engineering Research Center of Natural Products and New Drugs, Guangdong Provincial University Engineering Technology Research Center of Natural Products and Drugs, Guangdong Pharmaceutical University, Guangzhou 510006, China.

Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China.

出版信息

Molecules. 2019 Jan 31;24(3):514. doi: 10.3390/molecules24030514.

DOI:10.3390/molecules24030514
PMID:30709014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6385166/
Abstract

Chitooligosaccharide is beneficial for inhibiting dyslipidemia and reducing atherosclerotic and hyperlipidemic risk. The purpose of this study was to investigate the cholesterol-regulating effects and potential mechanisms of Chitooligosaccharide tablets (CFTs) in high-fat diet-induced hyperlipidemic rats. The results revealed that CFTs can regulate serum lipid levels in hyperlipidemic rats in a dosage-dependent manner. Synchronously, gene expressions related to cholesterol excretion were upregulated in a dosage-dependent manner, including cholesterol 7α-hydroxylase (CYP7A1), liver X receptor α (LXRA), peroxisome proliferation-activated receptor-α (PPARα) and low-density lipoprotein receptor (LDLR), whereas cholesterol synthetic gene expressions including 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and sterol-responsive element binding protein-2 (SREBP2) were reduced. This work highlights that CFTs have potential as natural products to prevent and treat metabolic hyperlipidemia syndrome, probably due to the reduction of cholesterol biosynthesis and through cholesterol elimination; they also improve the pathological changes of liver tissue in rats, alleviate liver damage, maintain normal lipid metabolism in the liver, ameliorate hepatic glycolipid disorders and accelerate TC operation, and reduce blood lipid levels.

摘要

壳寡糖有益于抑制血脂异常，降低动脉粥样硬化和高脂血症的风险。本研究旨在探讨壳寡糖片（CFT）对高脂饮食诱导的高脂血症大鼠的调脂作用及其潜在机制。结果表明，CFT 可在一定剂量范围内调节高脂血症大鼠的血清脂质水平。同时，胆固醇排泄相关基因的表达也呈剂量依赖性上调，包括胆固醇 7α-羟化酶（CYP7A1）、肝 X 受体α（LXRA）、过氧化物酶体增殖物激活受体-α（PPARα）和低密度脂蛋白受体（LDLR），而胆固醇合成基因的表达，包括 3-羟-3-甲基戊二酰基辅酶 A 还原酶（HMGCR）和固醇调节元件结合蛋白-2（SREBP2）则降低。本研究提示 CFT 可能作为天然产物用于预防和治疗代谢性高脂血症综合征，这可能是由于胆固醇生物合成减少和胆固醇排泄增加所致；同时，CFT 还能改善大鼠肝组织的病理变化，减轻肝损伤，维持肝脏正常的脂代谢，改善肝糖脂代谢紊乱，加速 TC 运转，降低血脂水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/55139af09493/molecules-24-00514-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/8cfbeaa1dad8/molecules-24-00514-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/82693a4214d6/molecules-24-00514-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/d1250b549169/molecules-24-00514-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/39e7fce58746/molecules-24-00514-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/5dcb956e8404/molecules-24-00514-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/3bf57e95970d/molecules-24-00514-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/dd82beed56e1/molecules-24-00514-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/3434d7ed4b81/molecules-24-00514-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/49eb2e3f63a6/molecules-24-00514-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/55139af09493/molecules-24-00514-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/8cfbeaa1dad8/molecules-24-00514-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/82693a4214d6/molecules-24-00514-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/d1250b549169/molecules-24-00514-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/39e7fce58746/molecules-24-00514-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/5dcb956e8404/molecules-24-00514-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/3bf57e95970d/molecules-24-00514-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/dd82beed56e1/molecules-24-00514-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/3434d7ed4b81/molecules-24-00514-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/49eb2e3f63a6/molecules-24-00514-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d273/6385166/55139af09493/molecules-24-00514-g010.jpg

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3
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7
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8
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