用于类风湿性关节炎非侵入性光热治疗的集成纳米材料。

Integrated nanomaterials for non-invasive photothermal therapy of rheumatoid arthritis.

机构信息

National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Palaj, Gandhinagar 382355, Gujarat, India.

出版信息

Drug Discov Today. 2021 Oct;26(10):2315-2328. doi: 10.1016/j.drudis.2021.04.026. Epub 2021 May 5.

DOI:10.1016/j.drudis.2021.04.026

PMID:33962037

Abstract

Rheumatoid arthritis (RA) is a chronic systemic inflammatory autoimmune disease that causes swelling, redness, and arthralgia of multiple joints. Despite significant research and development on the treatment modalities for RA, there is still no established effective treatment option for eradicating joint damage and inflammation. In recent years, photothermal therapy (PTT) has emerged as a practical approach to treat RA. In this review, we outline various factors that affect the effective treatment of RA. Moreover, we discuss various PTT-based nanomaterials that can be used to treat RA.

摘要

类风湿关节炎（RA）是一种慢性全身性炎症性自身免疫性疾病，可导致多个关节肿胀、发红和关节痛。尽管对 RA 的治疗方法进行了大量的研究和开发，但仍没有一种有效的治疗方法可以消除关节损伤和炎症。近年来，光热疗法（PTT）已成为治疗 RA 的一种实用方法。在这篇综述中，我们概述了影响 RA 有效治疗的各种因素。此外，我们还讨论了可用于治疗 RA 的各种基于 PTT 的纳米材料。