College of Chemistry, Institute of Analytical Chemistry for Life Science, Zhengzhou Key Laboratory of Functional Nanomaterial and Medical Theranostic, Zhengzhou University, Zhengzhou 450001, P. R. China.
Nanoscale. 2021 May 20;13(19):8751-8772. doi: 10.1039/d1nr00323b.
The development of robust materials for treating diseases through non-invasive photothermal therapy (PTT) has attracted increasing attention in recent years. Among various types of nanomaterials, inorganic nanomaterials with strong absorption in the near-infrared (NIR) window can be employed as high-efficiency photothermal agents to treat cancer and bacterial infections. In addition, inorganic nanomaterials can be easily combined with other drugs or chemical reagents to construct multifunctional nanomaterials to cascade stimulation responses, enhance therapeutic effects, and perform precise medical treatments. In this review, focusing on the latest developments of inorganic nanomaterials in photothermal therapy, we firstly introduced the light-to-heat conversion mechanism of inorganic nanomaterials. Secondly, we summarized the application of common inorganic nanomaterials, such as metallic nanoparticles, transition metal oxide nanoparticles and two dimensional (2D) nanosheets. In addition, the strategy of developing multifunctional nano-platforms with excellent biocompatibility as well as good targeted capability was also expounded. Finally, challenges and new perspectives for designing effective inorganic nanomaterial-based nanosystems for photothermal assisted therapy were also discussed.
近年来，通过非侵入性光热疗法（PTT）治疗疾病的稳健材料的发展引起了越来越多的关注。在各种类型的纳米材料中，在近红外（NIR）窗口具有强吸收的无机纳米材料可用作高效光热剂来治疗癌症和细菌感染。此外，无机纳米材料可以很容易地与其他药物或化学试剂结合，构建多功能纳米材料，以级联刺激反应、增强治疗效果和进行精确的医疗。在这篇综述中，我们重点介绍了无机纳米材料在光热疗法中的最新发展，首先介绍了无机纳米材料的光热转换机制。其次，我们总结了常见无机纳米材料的应用，如金属纳米粒子、过渡金属氧化物纳米粒子和二维（2D）纳米片。此外，还阐述了开发具有优异生物相容性和良好靶向能力的多功能纳米平台的策略。最后，还讨论了设计用于光热辅助治疗的有效基于无机纳米材料的纳米系统的挑战和新视角。
