Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 91886-17871, Iran.
Department of Chemistry, Shahid Bahonar University of Kerman, Kerman 761691411, Iran.
Int J Mol Sci. 2021 Mar 18;22(6):3092. doi: 10.3390/ijms22063092.
Nanomaterials have received increasing attention due to their unique chemical and physical properties for the treatment of rheumatoid arthritis (RA), the most common complex multifactorial joint-associated autoimmune inflammatory disorder. RA is characterized by an inflammation of the synovium with increased production of proinflammatory cytokines (IL-1, IL-6, IL-8, and IL-10) and by the destruction of the articular cartilage and bone, and it is associated with the development of cardiovascular disorders such as heart attack and stroke. While a number of imaging tools allow for the monitoring and diagnosis of inflammatory arthritis, and despite ongoing work to enhance their sensitivity and precision, the proper assessment of RA remains difficult particularly in the early stages of the disease. Our goal here is to describe the benefits of applying various nanomaterials as next-generation RA imaging and detection tools using contrast agents and nanosensors and as improved drug delivery systems for the effective treatment of the disease.
由于纳米材料具有独特的化学和物理特性，因此越来越受到关注，可用于治疗类风湿关节炎 (RA)，这是最常见的复杂多因素关节相关自身免疫性炎症性疾病。RA 的特征是滑膜炎症，促炎细胞因子 (IL-1、IL-6、IL-8 和 IL-10) 产生增加，以及关节软骨和骨破坏，并与心脏病发作和中风等心血管疾病的发展有关。虽然有许多成像工具可用于监测和诊断炎症性关节炎，并且尽管正在努力提高其敏感性和精度，但 RA 的正确评估仍然很困难，尤其是在疾病的早期阶段。我们的目标是描述将各种纳米材料作为下一代 RA 成像和检测工具（使用造影剂和纳米传感器）以及作为改善药物输送系统的应用的好处，以有效治疗该疾病。
