乙型肝炎病毒感染患者循环免疫复合物中抗-HBsAg抗体的IgG亚类组成
IgG subclass composition of antibodies to HBsAg in circulating immune complexes from patients with hepatitis B virus infections.
作者信息
Rath S, Devey M E
机构信息
Department of Medical Microbiology, London School of Hygiene and Tropical Medicine, UK.
出版信息
Clin Exp Immunol. 1988 Apr;72(1):164-7.
Abstract
The IgG subclass of antibody associated with hepatitis B surface antigen (HBsAg) in circulating immune complexes (CIC) from patients with either acute or chronic hepatitis B virus (HBV) infections was measured using an isotype and antigen-specific ELISA. All patients were HBsAg positive but were negative for free anti-HBs antibody. The subclass of antibody associated with HBsAg in CIC in both groups was predominantly IgG1 and IgG4. This is in contrast to free anti-HBs in convalescent sera from patients recovering from HBV infection, which are highly restricted to IgG1 and IgG3. The finding of high levels of IgG4 antibodies in CIC suggest that CIC containing this subclass may be cleared less efficiently than CIC containing antibodies of other subclasses. Formation of these CIC may be an important factor in the progression of infection to chronicity and may also be involved in the antigen-specific immunosuppression seen in early acute and chronic HBV infections.
摘要
采用同型和抗原特异性酶联免疫吸附测定法，对急性或慢性乙型肝炎病毒（HBV）感染患者循环免疫复合物（CIC）中与乙型肝炎表面抗原（HBsAg）相关的抗体IgG亚类进行了检测。所有患者HBsAg均为阳性，但游离抗-HBs抗体为阴性。两组患者CIC中与HBsAg相关的抗体亚类主要为IgG1和IgG4。这与HBV感染康复患者恢复期血清中的游离抗-HBs相反，后者高度局限于IgG1和IgG3。CIC中IgG4抗体水平较高这一发现表明，含有该亚类的CIC可能比含有其他亚类抗体的CIC清除效率更低。这些CIC的形成可能是感染发展为慢性的一个重要因素，也可能参与了早期急性和慢性HBV感染中所见的抗原特异性免疫抑制。
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