微粒体抗体和甲状腺球蛋白抗体活性在免疫球蛋白G亚类中的分布情况。
The distribution of microsomal and thyroglobulin antibody activity among the IgG subclasses.
作者信息
Parkes A B, McLachlan S M, Bird P, Rees Smith B
出版信息
Clin Exp Immunol. 1984 Jul;57(1):239-43.
Abstract
The IgG subclass distribution of autoantibodies to thyroglobulin (TgAb) and thyroid microsomes (MicAb) in 13 Hashimoto's sera has been investigated using an ELISA technique based on monoclonal anti-subclass antibodies. Considerable subclass restriction was observed with TgAb predominantly but not exclusively associated with IgG4 (mean %TgAb activity associated with IgG4 = 60%) and MicAb predominantly associated with IgG 1 (mean = 49%) and IgG4 (mean = 38%). The tendency for TgAb to be associated with IgG4 accorded with the weak complement fixing properties of this antibody whereas the association of MicAb with IgG1 was consistent with its complement fixing and cytotoxic properties.
摘要
运用基于单克隆抗亚类抗体的酶联免疫吸附测定（ELISA）技术，对13例桥本氏血清中抗甲状腺球蛋白自身抗体（TgAb）和抗甲状腺微粒体自身抗体（MicAb）的IgG亚类分布情况进行了研究。观察到TgAb存在显著的亚类限制，主要但并非仅与IgG4相关（与IgG4相关的TgAb活性平均百分比 = 60%），而MicAb主要与IgG1相关（平均 = 49%）以及IgG4相关（平均 = 38%）。TgAb与IgG4相关的趋势与其补体固定特性较弱相符，而MicAb与IgG1的关联与其补体固定和细胞毒性特性一致。
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