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Human organ-specific autoimmune disease. Molecular cloning and expression of an autoantibody gene repertoire for a major autoantigen reveals an antigenic immunodominant region and restricted immunoglobulin gene usage in the target organ.人类器官特异性自身免疫性疾病。针对一种主要自身抗原的自身抗体基因库的分子克隆与表达揭示了一个抗原性免疫显性区域以及靶器官中受限的免疫球蛋白基因使用情况。
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Functional analysis of T and B cells from blood and thyroid tissue in Hashimoto's disease.桥本氏病患者血液和甲状腺组织中T细胞和B细胞的功能分析。
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本文引用的文献

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An enzyme-linked immunoassay for thyroid microsomal antibodies.一种用于检测甲状腺微粒体抗体的酶联免疫测定法。
J Immunol Methods. 1982 Dec 17;55(2):155-68. doi: 10.1016/0022-1759(82)90028-x.
2
IgG subclass distribution in organ specific autoantibodies. The relationship to complement fixing ability.器官特异性自身抗体中的IgG亚类分布。与补体结合能力的关系。
Clin Exp Immunol. 1983 Apr;52(1):61-6.
3
Monoclonal antibodies (McAbs) to determinants on human gamma chains: properties of antibodies showing subclass restriction or subclass specificity.针对人γ链上决定簇的单克隆抗体（McAbs）：表现出亚类限制或亚类特异性的抗体特性。
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4
Immunochemical quantitation of antigens by single radial immunodiffusion.通过单向辐射免疫扩散法对抗原进行免疫化学定量。
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Biological activities of immunoglobulins of different classes and subclasses.不同类别和亚类免疫球蛋白的生物学活性
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Human immunoglobulins: classes, subclasses, genetic variants, and idiotypes.人免疫球蛋白：类别、亚类、基因变体和独特型。
Adv Immunol. 1973;16:1-59. doi: 10.1016/s0065-2776(08)60295-3.
7
pH gradient elution of human IgG1, IgG2 and IgG4 from protein A-sepharose.从蛋白A-琼脂糖凝胶上对人IgG1、IgG2和IgG4进行pH梯度洗脱。
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微粒体抗体和甲状腺球蛋白抗体活性在免疫球蛋白G亚类中的分布情况。

The distribution of microsomal and thyroglobulin antibody activity among the IgG subclasses.

作者信息

Parkes A B, McLachlan S M, Bird P, Rees Smith B

出版信息

Clin Exp Immunol. 1984 Jul;57(1):239-43.

PMID:6430614
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1536069/
Abstract

The IgG subclass distribution of autoantibodies to thyroglobulin (TgAb) and thyroid microsomes (MicAb) in 13 Hashimoto's sera has been investigated using an ELISA technique based on monoclonal anti-subclass antibodies. Considerable subclass restriction was observed with TgAb predominantly but not exclusively associated with IgG4 (mean %TgAb activity associated with IgG4 = 60%) and MicAb predominantly associated with IgG 1 (mean = 49%) and IgG4 (mean = 38%). The tendency for TgAb to be associated with IgG4 accorded with the weak complement fixing properties of this antibody whereas the association of MicAb with IgG1 was consistent with its complement fixing and cytotoxic properties.

摘要

运用基于单克隆抗亚类抗体的酶联免疫吸附测定（ELISA）技术，对13例桥本氏血清中抗甲状腺球蛋白自身抗体（TgAb）和抗甲状腺微粒体自身抗体（MicAb）的IgG亚类分布情况进行了研究。观察到TgAb存在显著的亚类限制，主要但并非仅与IgG4相关（与IgG4相关的TgAb活性平均百分比 = 60%），而MicAb主要与IgG1相关（平均 = 49%）以及IgG4相关（平均 = 38%）。TgAb与IgG4相关的趋势与其补体固定特性较弱相符，而MicAb与IgG1的关联与其补体固定和细胞毒性特性一致。