全视网膜激光光凝的 3D 模拟中视锥细胞密度的影响。
Impact of photoreceptor density in a 3D simulation of panretinal laser photocoagulation.
机构信息
Department of Ophthalmology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, E-7, Suita, Osaka, 565-0871, Japan.
Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, Suita, Osaka, Japan.
出版信息
BMC Ophthalmol. 2021 May 7;21(1):200. doi: 10.1186/s12886-021-01945-z.
BACKGROUND
During panretinal photocoagulation (PRP), the outer retina, especially the photoreceptors, are destroyed. During such procedures, the impact of the retinal photocoagulation, which is performed in the same photocoagulated area, may change if it is applied to different locations with different photoreceptor densities. Thus, we aimed to evaluate the influence of photoreceptor density on PRP.
METHODS
We constructed a three-dimensional (3D) average distribution of photoreceptors with 3D computer-aided design (CAD) software using previously derived photoreceptor density data and calculated the number of photoreceptors destroyed by scatter PRP and full-scatter PRP (size 400-μm on the retina, spacing 1.0 spot) using a geometry-based simulation. To investigate the impact of photoreceptor density on PRP, we calculated the ratio of the number of photoreceptors destroyed to the total number of photoreceptors, termed the photoreceptor destruction index.
RESULTS
In this 3D simulation, the total number of photoreceptors was 96,571,900. The total number of photoreceptors destroyed by scatter PRP and full-scatter PRP were 15,608,200 and 19,120,600, respectively, and the respective photoreceptor destruction indexes were 16.2 and 19.8%, respectively.
CONCLUSIONS
Scatter PRP is expected to have 4/5 of the number of photoreceptors destroyed by full-scatter PRP.
背景
在全视网膜光凝（PRP）过程中，外视网膜，尤其是光感受器，会被破坏。在进行此类手术时，如果在不同的光感受器密度区域施加相同的视网膜光凝，那么视网膜光凝的影响可能会发生变化。因此，我们旨在评估光感受器密度对 PRP 的影响。
方法
我们使用之前得出的光感受器密度数据，通过三维计算机辅助设计（CAD）软件构建三维平均光感受器分布，并使用基于几何的模拟计算散斑 PRP 和全散斑 PRP（视网膜上的光斑大小为 400-μm，间隔为 1.0 个光斑）破坏的光感受器数量。为了研究光感受器密度对 PRP 的影响，我们计算了被破坏的光感受器数量与总光感受器数量的比值，称为光感受器破坏指数。
结果
在这个三维模拟中，总光感受器数量为 96,571,900。散斑 PRP 和全散斑 PRP 破坏的总光感受器数量分别为 15,608,200 和 19,120,600，相应的光感受器破坏指数分别为 16.2%和 19.8%。
结论
散斑 PRP 预计会破坏全散斑 PRP 所破坏的光感受器数量的 4/5。
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