Amsterdam University Medical Centres, University of Amsterdam, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, the Netherlands.
ICF, Durham, NC, USA.
Regul Toxicol Pharmacol. 2021 Jul;123:104940. doi: 10.1016/j.yrtph.2021.104940. Epub 2021 May 6.
Systematic reviews (SRs) are common practice in clinical and public health research, but less common in non-human animal research. Systematic reviews of animal studies can be valuable to inform clinical research, to evaluate the need for further animal experiments on a given topic, and to assess the hazard of an environmental exposure in the evaluation of toxicological studies. In the last 10 years, there has been an increase in the number of SRs of animal research, as well as several publications with detailed guidance on how to perform high-quality systematic reviews of experimental animal studies. In order to evaluate current analytical approaches used in SRs of animal studies, easily identify all systematic reviews on a specific topic, and subsequently the original animal studies and their results and promote awareness and understanding of these emerging approaches, we compiled a database of SRs of animal studies. The database was developed using a rigorous, systematic approach and covers a broad range of research fields: preclinical research, toxicology, environmental health, and veterinary medicine. The database currently includes 3113 SRs of animal studies (search date June 2019). In addition to bibliographical information, data on whether or not a risk of bias assessment and meta-analysis were conducted were extracted. For future users, the search features of the database provide users with a platform to identify and select SRs with a particular characteristic for export to Microsoft Word or Microsoft Excel. From there, users may perform additional data extraction to meet their research needs. The database is freely available at www.Mendeley.com (link). The database provides methodologists a comprehensive source that can be used to explore and advance the current methodology applied to SRs of animal studies, and can help researchers to easily identify all systematic reviews on a specific topic, and subsequently the original animal studies and their results and avoid duplication and unnecessary animal research.
系统评价（SR）在临床和公共卫生研究中很常见，但在非人类动物研究中则较少见。对动物研究进行系统评价可以为临床研究提供信息，评估在特定主题上进一步进行动物实验的必要性，并评估环境暴露在毒理学研究评估中的危害。在过去的 10 年中，动物研究的 SR 数量有所增加，并且有几篇出版物详细介绍了如何进行高质量的实验动物研究系统评价。为了评估当前在动物研究 SR 中使用的分析方法，方便地识别特定主题的所有系统评价，以及随后的原始动物研究及其结果，并提高对这些新兴方法的认识和理解，我们编制了一个动物研究 SR 数据库。该数据库是使用严格、系统的方法开发的，涵盖了广泛的研究领域：临床前研究、毒理学、环境卫生和兽医。该数据库目前包含 3113 篇动物研究的 SR（搜索日期为 2019 年 6 月）。除了书目信息外，还提取了是否进行偏倚风险评估和荟萃分析的数据。对于未来的用户，数据库的搜索功能为用户提供了一个平台，可以识别和选择具有特定特征的 SR，以便以 Microsoft Word 或 Microsoft Excel 的格式导出。然后，用户可以根据需要进行额外的数据提取。该数据库可在 www.Mendeley.com（链接）免费获取。该数据库为方法学家提供了一个全面的资源，可以用来探索和推进当前应用于动物研究 SR 的方法学，并可以帮助研究人员方便地识别特定主题的所有系统评价，以及随后的原始动物研究及其结果，避免重复和不必要的动物研究。
