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精子DNA完整性评估：对家畜物种辅助生殖技术生育结果的影响

The Assessment of Sperm DNA Integrity: Implications for Assisted Reproductive Technology Fertility Outcomes across Livestock Species.

作者信息

Robertson Maya J, Chambers Caitlin, Spanner Eloise A, de Graaf Simon P, Rickard Jessica P

机构信息

Faculty of Science, School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW 2006, Australia.

出版信息

Biology (Basel). 2024 Jul 17;13(7):539. doi: 10.3390/biology13070539.

DOI:10.3390/biology13070539
PMID:39056730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11273975/
Abstract

Sperm DNA integrity is increasingly considered a useful measure of semen quality in mammalian reproduction. However, the definition of DNA integrity, the ideal means by which it should be measured, and its predictive value for fertility remain a topic of much discussion. With an emphasis on livestock species, this review discusses the assays that have been developed to measure DNA integrity as well as their correlation with in vitro and in vivo fertility.

摘要

精子DNA完整性在哺乳动物繁殖中越来越被视为精液质量的一项有用指标。然而，DNA完整性的定义、测量它的理想方法以及其对生育能力的预测价值仍是一个备受讨论的话题。本综述重点关注家畜物种，讨论了已开发出的用于测量DNA完整性的检测方法及其与体外和体内生育能力的相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/875b/11273975/eb826545d46a/biology-13-00539-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/875b/11273975/eb826545d46a/biology-13-00539-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/875b/11273975/eb826545d46a/biology-13-00539-g001.jpg

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Int J Mol Sci. 2021 May 30;22(11):5857. doi: 10.3390/ijms22115857.
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Developing a database of systematic reviews of animal studies.建立动物研究系统评价数据库。
Regul Toxicol Pharmacol. 2021 Jul;123:104940. doi: 10.1016/j.yrtph.2021.104940. Epub 2021 May 6.
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Differences in sperm functionality and intracellular metabolites in Norwegian Red bulls of contrasting fertility.
家畜精液质量的决定遗传标记。
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