Department of Pharmacology, Rīga Stradiņš University, Riga, Latvia.
Department of Veterinary Medicine, University of Sassari, Sassari, Italy.
Res Vet Sci. 2021 Jul;137:111-126. doi: 10.1016/j.rvsc.2021.04.031. Epub 2021 Apr 30.
A potent third-generation antimicrobial fluoroquinolone drug, levofloxacin was introduced into human clinical practice in 1993. Levofloxacin is also used in veterinary medicine, however its use is limited: it is completely banned for veterinary use in the EU, and used extralabel in only companion animals in the USA. Since its introduction to clinical practice, many studies have been published on levofloxacin in animal species, including pharmacokinetic studies, tissue drug depletion, efficacy, and animal microbial isolate susceptibility to levofloxacin. This literature overview highlights the most clinically relevant and scientifically important levofloxacin studies linked to the field of veterinary medicine.
一种强效的第三代抗菌氟喹诺酮类药物左氧氟沙星于 1993 年引入临床应用。左氧氟沙星也用于兽医领域，但使用受到限制：在欧盟完全禁止用于兽医，仅在美国的伴侣动物中被超说明书使用。自临床应用以来，已经发表了许多关于动物种属中左氧氟沙星的研究，包括药代动力学研究、组织药物耗竭、疗效以及动物微生物分离株对左氧氟沙星的敏感性。本文献综述强调了与兽医领域最相关和最重要的左氧氟沙星研究。
