Horsager Jacob, Tiroke Lasse Hubertus, Skjærbæk Casper, Knudsen Karoline, Fedorova Tatyana D, Okkels Niels, Borghammer Per
Department of Nuclear Medicine and PET, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, J220, 8200, Aarhus N, Denmark.
Department of Nuclear Medicine and PET, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, J220, 8200, Aarhus N, Denmark.
Parkinsonism Relat Disord. 2021 Jun;87:56-60. doi: 10.1016/j.parkreldis.2021.04.027. Epub 2021 Apr 30.
Autonomic denervation in patients with Parkinson's disease (PD) and isolated REM-sleep behavior disorder (iRBD) could impede gallbladder function leading to increased fasting gallbladder volume (fGBV) and higher risk of gallstones. We aimed to determine fGBV in patients with PD, iRBD, and healthy controls (HCs).
We included 189 subjects; 100 patients with PD, 21 with iRBD, and 68 HCs. fGBV was determined from abdominal CT scans, and radiopaque gallstone frequency was evaluated.
Median fGBV was 35.7 ml in patients with PD, 31.8 ml in iRBD, and 27.8 ml in HCs (Kruskal-Wallis test: P = 0.0055). Post-tests adjusted for multiple comparison revealed a significant group difference between patients with PD and HCs (P = 0.0038). In the PD group, 23% had enlarged fGBV (cut-off at mean + 2 x standard deviation (SD) in the HC group). No difference in fGBV was observed between iRBD and the other two groups. The total prevalence of gallstones was 6.4% with no differences between the three groups.
Almost a quarter of patients with PD in our cohort exhibited increased fGBV. This study illuminates a potentially overlooked topic in PD research and calls for more studies on biliary dysfunction.
帕金森病（PD）患者和孤立性快速眼动睡眠行为障碍（iRBD）患者的自主神经去神经支配可能会妨碍胆囊功能，导致空腹胆囊容积（fGBV）增加和胆结石风险升高。我们旨在测定PD患者、iRBD患者和健康对照者（HCs）的fGBV。
我们纳入了189名受试者；100名PD患者、21名iRBD患者和68名HCs。通过腹部CT扫描测定fGBV，并评估不透X线胆结石的发生率。
PD患者的fGBV中位数为35.7 ml，iRBD患者为31.8 ml，HCs为27.8 ml（Kruskal-Wallis检验：P = 0.0055）。经多重比较调整后的事后检验显示，PD患者与HCs之间存在显著的组间差异（P = 0.0038）。在PD组中，23%的患者fGBV增大（以HC组的均值 + 2倍标准差（SD）为临界值）。iRBD与其他两组之间未观察到fGBV的差异。胆结石的总患病率为6.4%，三组之间无差异。
在我们的队列中，近四分之一的PD患者表现出fGBV增加。本研究阐明了PD研究中一个可能被忽视的主题，并呼吁对胆汁功能障碍进行更多研究。
