ARC Centre of Excellence in Convergent BioNano Science and Technology and Future Industries Institute, University of South Australia, Mawson Lakes Campus, Mawson Lakes, South Australia, 5095, Australia.
Flinders Health and Medical Research Institute, Flinders University, Bedford Park, South Australia, 5042, Australia.
Trends Biotechnol. 2021 Nov;39(11):1221-1235. doi: 10.1016/j.tibtech.2021.03.009. Epub 2021 May 5.
Driven by a lack of appropriate human placenta models, recent years have seen the introduction of bioengineered in vitro models to better understand placental health and disease. Thus far, the focus has been on the maternal-foetal barrier. However, there are many other physiologically and pathologically significant aspects of the placenta that would benefit from state-of-the-art bioengineered models, in particular, integrating advanced culture systems with contemporary biological concepts such as organoids. This critical review defines and discusses the key parameters required for the development of physiologically relevant in vitro models of the placenta. Specifically, it highlights the importance of cell type, mechanical forces, and culture microenvironment towards the use of physiologically relevant models to improve the understanding of human placental function and dysfunction.
由于缺乏合适的人胎盘模型，近年来引入了生物工程体外模型来更好地理解胎盘健康和疾病。到目前为止，研究重点一直是母胎屏障。然而，胎盘还有许多其他在生理和病理上都很重要的方面，可以从最先进的生物工程模型中受益，特别是将先进的培养系统与器官样体等当代生物学概念相结合。这篇批判性评论定义并讨论了开发胎盘生理相关体外模型所需的关键参数。具体来说，它强调了细胞类型、机械力和培养微环境对于使用生理相关模型来改善对人胎盘功能和功能障碍的理解的重要性。
