Department of Obstetrics and Gynecology, Seoul National University, Bundang Hospital, Seoul National University College of Medicine, Republic of Korea; Department of Medicine, Harvard Medical School, Brigham Women's Hospital, Boston, MA, USA.
Department of Medicine, Harvard Medical School, Brigham Women's Hospital, Boston, MA, USA.
EBioMedicine. 2023 Sep;95:104780. doi: 10.1016/j.ebiom.2023.104780. Epub 2023 Aug 30.
During the last decade, organs-on-chips or organoids microphysiological analysis platforms (MAP) have garnered attention in the practical applications of disease models, drug discovery, and developmental biology. Research on pregnant women has firm limitations due to ethical issues; thus, remodelling human pregnancy in vitro is highly beneficial for treatment modality development via disease remodelling or drug monitoring. This review highlights current efforts in bioengineering devices to reproduce human pregnancy and emphasises the significant convergence of biology, engineering, and maternal-foetal medicine. First, we review recent achievements in culturing cells from tissues involved in pregnancy; specifically, trophoblasts from the placenta. Second, we highlight developments in the reconstitution of pregnancy-related female reproductive organs across several structural and functional interpretations. Last, we examine research on the fundamental comprehension of pregnancy-associated diseases to find bioengineering solutions. Recreating human pregnancy through an engineered model is naturally complex; nevertheless, challenges are inevitable to progress precision medicine.
在过去的十年中，器官芯片或类器官微生理分析平台 (MAP) 在疾病模型、药物发现和发育生物学的实际应用中引起了关注。由于伦理问题，对孕妇的研究有明确的限制；因此，通过疾病重塑或药物监测，在体外重塑人类妊娠对治疗方式的发展非常有益。本综述强调了当前生物工程设备在重现人类妊娠方面的努力，并强调了生物学、工程学和母胎医学的重要融合。首先，我们回顾了培养与妊娠相关组织的细胞的最新进展，特别是胎盘的滋养层细胞。其次，我们重点介绍了几个结构和功能解释中妊娠相关女性生殖器官重建的进展。最后，我们研究了与妊娠相关疾病的基本理解，以找到生物工程解决方案。通过工程模型重现人类妊娠自然是复杂的；然而，要取得进展，挑战是不可避免的。
