Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Clinical Skill Training Center, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Cancer Epidemiol. 2021 Aug;73:101946. doi: 10.1016/j.canep.2021.101946. Epub 2021 May 6.
Increasing epidemiological evidence suggests that diabetes may be associated with meningioma risk, but the evidence supporting this association is still inconclusive. Therefore, we performed a meta-analysis of all eligible observational studies to evaluate the potential association of diabetes with meningioma risk.
A comprehensive literature search was performed in the PubMed, Web of Science and Cochrane Library databases up to November 30, 2020. A random-effects model was applied to calculate the pooled effect size (ES) and its 95 % confidence interval (CI).
Eight studies were included in this study. In a random-effects pooled analysis, the results showed that DM (diabetes mellitus) increased the risk of meningioma (ES 1.17, 95 % CI: 1.02-1.35, P = 0.027). In subgroup analyses, DM increased the risk of meningioma in women (ES: 1.19, 95 % CI: 1.02-1.40, P = 0.027) and men (ES: 1.53, 95 % CI: 1.25-1.88, P = 0.000). This effect was not observed in the postmenopausal group (ES: 1.18, 95 % CI: 0.64-2.18, P = 0.597).
Our meta-analysis showed that DM increases the risk of meningioma, but the association was only present in some subgroups. This conclusion should be further confirmed.
越来越多的流行病学证据表明，糖尿病可能与脑膜瘤风险相关，但支持这种关联的证据仍不确定。因此，我们对所有合格的观察性研究进行了荟萃分析，以评估糖尿病与脑膜瘤风险之间的潜在关联。
我们在 PubMed、Web of Science 和 Cochrane Library 数据库中进行了全面的文献检索，检索截至 2020 年 11 月 30 日。应用随机效应模型计算汇总效应大小（ES）及其 95%置信区间（CI）。
本研究纳入了 8 项研究。在随机效应汇总分析中，结果表明糖尿病（DM）增加了脑膜瘤的风险（ES 1.17，95%CI：1.02-1.35，P=0.027）。在亚组分析中，DM 增加了女性（ES：1.19，95%CI：1.02-1.40，P=0.027）和男性（ES：1.53，95%CI：1.25-1.88，P=0.000）患脑膜瘤的风险。但在绝经后女性中未观察到这种影响（ES：1.18，95%CI：0.64-2.18，P=0.597）。
我们的荟萃分析表明，DM 增加了脑膜瘤的风险，但这种关联仅存在于某些亚组中。这一结论需要进一步证实。
