Department of Neurosurgery, First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou 310000, People's Republic of China.
Cancer Epidemiol. 2013 Feb;37(1):39-45. doi: 10.1016/j.canep.2012.09.004. Epub 2012 Oct 24.
The relationship between smoking and the development of meningioma has been investigated in several epidemiological studies. However, the results of these studies are inconsistent. We conducted a meta-analysis in order to identify any potential association.
PubMed, the Cochrane Library, and EMBASE databases were searched to identify relevant articles that investigated the risk of meningioma following cigarette smoking. Two researchers evaluated study eligibility and extracted the data independently, and disagreements were resolved by discussion. The variables used to estimate the pooled risk of smoking in meningioma development were the multivariate-adjusted risk estimates presented in the literature.
Seven case-control and two cohort studies were included in this meta-analysis. The pooled estimated risks associated with ever smoking for meningioma were 1.02 (95% confidence interval (CI): 0.85-1.21) in the case-control studies, 0.93 (95% CI: 0.83-1.04) in the cohort studies and 0.95 (95% CI: 0.87-1.05, P = 0.32) in all studies when the cohort and case-control data were combined. Subgroup analyses suggested that the risk estimates were 1.49 (95% CI: 1.06-2.09, P = 0.02), 0.86 (95% CI: 0.65-1.13), 0.79 (95% CI: 0.50-1.25) and 0.84 (95% CI: 0.69-1.03) for men, women, current and past smoking respectively. Sensitivity analyses restricted to studies with different adjustments for confounders yielded similar results. No evidence of publication bias was observed.
Our meta-analysis suggests that there is no association between ever smoking and the risk of meningioma. However, a small but significant risk elevation is present among men smokers.
吸烟与脑膜瘤发展之间的关系已在几项流行病学研究中进行了调查。然而，这些研究的结果并不一致。我们进行了一项荟萃分析，以确定任何潜在的关联。
检索了 PubMed、Cochrane 图书馆和 EMBASE 数据库，以确定调查吸烟后脑膜瘤风险的相关文章。两名研究人员独立评估了研究的合格性并提取了数据，如果存在分歧，则通过讨论解决。用于估计吸烟与脑膜瘤发展之间的汇总风险的变量是文献中报告的多变量调整风险估计。
本荟萃分析纳入了 7 项病例对照研究和 2 项队列研究。病例对照研究中，与曾经吸烟相关的脑膜瘤风险的汇总估计风险为 1.02（95%置信区间（CI）：0.85-1.21），队列研究中为 0.93（95% CI：0.83-1.04），当合并队列和病例对照数据时为 0.95（95% CI：0.87-1.05，P = 0.32）。亚组分析表明，风险估计值分别为 1.49（95% CI：1.06-2.09，P = 0.02）、0.86（95% CI：0.65-1.13）、0.79（95% CI：0.50-1.25）和 0.84（95% CI：0.69-1.03），用于男性、女性、当前和过去吸烟。仅对针对混杂因素进行不同调整的研究进行敏感性分析得出了相似的结果。未观察到发表偏倚的证据。
我们的荟萃分析表明，曾经吸烟与脑膜瘤的风险之间没有关联。然而，男性吸烟者的风险略有升高，但具有统计学意义。
