Department of Zoology, K.R.T. Arts, B.H. Commerce and A.M. Science College (KTHM College), Nashik 422002, MS, India.
Department of Zoology, Savitribai Phule Pune University, Pune 411007, MS, India.
Biomed Pharmacother. 2021 Jul;139:111634. doi: 10.1016/j.biopha.2021.111634. Epub 2021 May 6.
Alzheimer's disease (AD), a type of dementia, severely distresses different brain regions. Characterized by various neuropathologies, it interferes with cognitive functions and neuropsychiatrical controls. This progressive deterioration has negative impacts not only on an individual's daily activity but also on social and occupational life. The pharmacological approach has always remained in the limelight for the treatment of AD. However, this approach is condemned with several side effects. Henceforth, a change in treatment approach has become crucial. Plant-based natural products are garnering special attention due to lesser side effects associated with their use. The current review emphasizes the anti-AD properties of phytoconstituents, throws light on those under clinical trials, and compiles information on their specific mode of actions against AD-related different neuropathologies. The phytoconstituents alone or in combinations will surely help discover new potent drugs for the effective treatment of AD with lesser side effects than the currently available pharmacological treatment.
阿尔茨海默病（AD）是一种痴呆症，严重影响不同的大脑区域。其特征是存在多种神经病理学改变，干扰认知功能和神经精神控制。这种进行性恶化不仅对个人的日常活动，而且对社会和职业生活都有负面影响。药物治疗方法一直是 AD 治疗的焦点。然而，这种方法存在多种副作用。因此，治疗方法的改变变得至关重要。植物源性天然产物因其使用相关的副作用较小而受到特别关注。目前的综述强调了植物成分的抗 AD 特性，介绍了那些正在临床试验中的成分，并汇编了它们针对 AD 相关不同神经病理学的特定作用模式的信息。这些植物成分单独或联合使用，肯定有助于发现新的有效药物，用于有效治疗 AD，其副作用比目前可用的药物治疗更小。
