胃癌来源的外泌体通过靶向内皮细胞中 miR-29a/VEGF 轴将 circRNA 递送至促进血管生成。
Gastric cancer derived exosomes mediate the delivery of circRNA to promote angiogenesis by targeting miR-29a/VEGF axis in endothelial cells.
机构信息
Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Huanhuxi Road 18, Tianjin, 300060, China.
State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
出版信息
Biochem Biophys Res Commun. 2021 Jun 30;560:37-44. doi: 10.1016/j.bbrc.2021.04.099. Epub 2021 May 6.
Accumulating evidence has been found that circular RNA (circRNA) plays a critical role in the initiation and development of various diseases by modulating gene expression in the cytoplasm. However, the role of circ_0044366 (termed circ29) in gastric cancer (GC) has yet to be elusive. We detected that exosomal circ29 was confirmed to be highly expressed in GC and can significantly impair the proliferation, migration, tube formation of HUVEC by exosomal communication. Interestingly, this effect could be blocked by the effect of miR-29a. In brief, we confirmed that circ29, as a sponge of miR-29a, plays a responsible role in the occurrence and development of GC by regulating the VEGF pathway. Therefore, it may be used as a potential target for the treatment of GC.
越来越多的证据表明，环状 RNA（circRNA）通过在细胞质中调节基因表达，在各种疾病的发生和发展中起着关键作用。然而，circ_0044366（称为 circ29）在胃癌（GC）中的作用仍未被揭示。我们检测到，外泌体 circ29 在 GC 中被证实高度表达，并通过外泌体通讯显著损害 HUVEC 的增殖、迁移和管形成。有趣的是，这种效应可以被 miR-29a 的作用所阻断。简而言之，我们证实 circ29 作为 miR-29a 的海绵，通过调节 VEGF 通路在 GC 的发生和发展中起作用。因此，它可能被用作治疗 GC 的潜在靶点。
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