Lefevre M, Keen C L, Lönnerdal B, Hurley L S, Schneeman B O
J Nutr. 1985 Mar;115(3):359-68. doi: 10.1093/jn/115.3.359.
Male Sprague-Dawley rats (six per group) were fed an egg white-based diet containing 0 or 5 micrograms/g Cu with 1, 10, 100 or 1000 micrograms/g Zn. After 6 wk of feeding, the rats were killed, and the tissues were processed for trace element, lipid and lipoprotein analysis. Copper deficiency was associated with a higher concentration of plasma free cholesterol, high density lipoprotein (HDL) cholesterol and HDL apolipoproteins. Plasma total cholesterol was not significantly affected. No significant differences were noted in HDL lipid composition. However, HDL apo E and apo A-I concentrations were higher with copper deficiency. Lecithin:cholesterol acyltransferase (LCAT) was not affected in a consistent manner by copper status. Varying the amount of zinc in the diet did not produce significant changes in plasma total cholesterol, plasma free cholesterol, HDL cholesterol, or HDL apolipoprotein concentrations. However, HDL from zinc-deficient rats were enriched in free cholesterol and depleted in triglycerides. Furthermore, the concentration of HDL apo C increased as the level of dietary zinc increased.
雄性斯普拉格-道利大鼠（每组6只）被喂食以蛋清为基础的饮食，其中铜含量为0或5微克/克，锌含量为1、10、100或1000微克/克。喂养6周后，处死大鼠，并对组织进行微量元素、脂质和脂蛋白分析。铜缺乏与血浆游离胆固醇、高密度脂蛋白（HDL）胆固醇和HDL载脂蛋白浓度升高有关。血浆总胆固醇未受到显著影响。HDL脂质组成未观察到显著差异。然而，铜缺乏时HDL载脂蛋白E和载脂蛋白A-I浓度较高。卵磷脂胆固醇酰基转移酶（LCAT）未因铜状态而受到一致影响。改变饮食中锌的含量未使血浆总胆固醇、血浆游离胆固醇、HDL胆固醇或HDL载脂蛋白浓度产生显著变化。然而，缺锌大鼠的HDL富含游离胆固醇且甘油三酯含量减少。此外，随着饮食锌水平的升高，HDL载脂蛋白C的浓度增加。
