Saratov State University, Saratov, Russia.
Lovelace Biomedical Research Institute, Albuquerque, NM, USA.
Adv Exp Med Biol. 2021;1269:197-202. doi: 10.1007/978-3-030-48238-1_31.
The blood-brain barrier (BBB) poses a significant challenge for drug delivery to the brain. The limitations of our knowledge about the nature of BBB explain the slow progress in the therapy of brain diseases and absence of methods for drug delivery to the brain in clinical practice. Here, we show that the BBB opens for high-molecular-weight compounds after exposure to loud sound (100 dB 370 Hz) in rats. The role of stress induced by loud sound and the systemic and molecular mechanisms behind it are discussed in the framework of the BBB. This opens an informative platform for novel fundamental knowledge about the nature of BBB and for the development of a noninvasive brain drug delivery technology.
血脑屏障（BBB）对向大脑输送药物构成了重大挑战。我们对 BBB 性质的了解有限，这解释了为什么在治疗脑部疾病方面进展缓慢，以及在临床实践中缺乏向大脑输送药物的方法。在这里，我们展示了在大鼠中，强声（100 分贝，370 赫兹）暴露后，BBB 会对高分子量化合物开放。本文在 BBB 的框架内讨论了强声引起的应激以及背后的全身和分子机制的作用。这为有关 BBB 性质的新的基础知识和非侵入性脑内药物输送技术的发展提供了一个有价值的平台。
