Facultad de Ciencias Veterinarias, Cátedra de Microbiología, Universidad de Buenos Aires, Buenos Aires, Argentina.
Facultad de Farmacia y Bioquímica, Instituto de Investigaciones en Bacteriología y Virología Molecular (IBaViM), Universidad de Buenos Aires, Buenos Aires, Argentina.
Zoonoses Public Health. 2021 Aug;68(5):516-526. doi: 10.1111/zph.12842. Epub 2021 May 8.
The widespread use of antimicrobial therapy in companion animals could lead to increased levels of resistance. Monitoring these levels is critical to understand not only the zoonotic threat of resistant bacteria but also the interspecies transmission of resistance mechanisms. However, data on resistance levels in companion animals of urban areas in Latin America are lacking. In this retrospective study, we analysed 23,922 isolates recovered from clinical samples of dogs and cats between 2011 and 2017. Growing trends of resistance to fluoroquinolones were observed in most bacterial species of veterinary importance with zoonotic potential (Enterobacterales, Pseudomonas and Staphylococcus). Furthermore, an increase of resistance levels to third-generation cephalosporins was also detected in Enterobacterales. Currently, Pseudomonas aeruginosa, Enterococcus spp. and Streptococcus spp. did not seem to represent a clinical challenge. A high proportion of multidrug-resistant (MDR) Enterobacterales isolated from urine was reported. It is interesting to outline that resistance to amikacin was exceptional. This study might be considered as a baseline for prospective antimicrobial resistance surveillance in companion animals in our region.
抗菌疗法在伴侣动物中的广泛应用可能导致耐药水平的升高。监测这些水平对于理解不仅是耐药细菌的人畜共患病威胁，还有耐药机制的种间传播至关重要。然而，关于拉丁美洲城市地区伴侣动物的耐药水平的数据却缺乏。在这项回顾性研究中，我们分析了 2011 年至 2017 年间从狗和猫的临床样本中分离出的 23922 株分离株。具有人畜共患潜力的兽医重要细菌（肠杆菌科、假单胞菌和葡萄球菌）对氟喹诺酮类药物的耐药性呈增长趋势。此外，肠杆菌科对第三代头孢菌素的耐药水平也有所增加。目前，铜绿假单胞菌、肠球菌属和链球菌属似乎没有构成临床挑战。从尿液中分离出的耐多药肠杆菌科的比例很高。值得注意的是，阿米卡星的耐药性异常罕见。本研究可以被认为是我们地区伴侣动物的前瞻性抗菌药物耐药性监测的基线。
