Department of Physical Therapy, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Department of Neuroscience, Institute for Research and Medical Consultation, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Disabil Rehabil. 2022 Aug;44(17):4775-4783. doi: 10.1080/09638288.2021.1919929. Epub 2021 May 9.
To study the factors which may contribute to quality of life (QOL) in patients with multiple sclerosis (pwMS) in Saudi Arabia.
175 pwMS and 71 age-, gender-, and BMI-matched healthy subjects participated in this cross-sectional study. QOL was studied by the multiple sclerosis quality of life-54 (MSQOL-54) while depression, disability, and fatigue were measured by the beck depression inventory-II (BDI-II), the expanded disability status scale (EDSS), and the modified fatigue impact scale (MFIS), respectively. The effects of demographic and clinical characteristics on MSQOL-54 were studied.
QOL was worse in pwMS. A better QOL in pwMS was linked to being male, having relapsing-remitting MS, having lower BMI, being employed, having a low disability, having no or minimal depression, and not fatigued. Age, disease duration, marital status, living status, and level of education did not affect the QOL. QOL showed a moderate to strong correlation with depression and fatigue and a weak correlation with EDSS. Depression and fatigue were the strongest predictors of QOL. Other predictors included gender and BMI but not EDSS.
Many of the factors which seem to influence QOL in pwMS are modifiable. Evaluation and management of such factors may improve QOL in pwMS.Implications for rehabilitationAssessment of QOL (using a proper tool) should be part of every pwMS evaluation.Depression and fatigue are the main predictors of QOL in pwMs, therefore, attention should be paid for their evaluation and management.Sexual dysfunction and pain should be assessed and managed early in the course of the disease.
研究可能影响沙特阿拉伯多发性硬化症（pwMS）患者生活质量（QOL）的因素。
本横断面研究纳入了 175 名 pwMS 患者和 71 名年龄、性别和 BMI 匹配的健康对照者。使用多发性硬化生活质量-54 量表（MSQOL-54）评估 QOL，使用贝克抑郁量表-II（BDI-II）、扩展残疾状况量表（EDSS）和修正疲劳影响量表（MFIS）评估抑郁、残疾和疲劳。研究了人口统计学和临床特征对 MSQOL-54 的影响。
pwMS 的 QOL 更差。pwMS 中更好的 QOL 与男性、复发缓解型 MS、较低的 BMI、就业、较低的残疾、无或轻度抑郁以及无疲劳有关。年龄、疾病持续时间、婚姻状况、居住状况和教育程度不影响 QOL。QOL 与抑郁和疲劳呈中度至强相关，与 EDSS 呈弱相关。抑郁和疲劳是 QOL 的最强预测因素。其他预测因素包括性别和 BMI，但不包括 EDSS。
许多似乎影响 pwMS QOL 的因素是可以改变的。评估和管理这些因素可能会改善 pwMS 的 QOL。
评估 QOL（使用适当的工具）应成为每一位 pwMS 评估的一部分。抑郁和疲劳是 pwMS 中 QOL 的主要预测因素，因此应注意评估和管理。性功能障碍和疼痛应在疾病早期进行评估和管理。
