Raji Ilham, Bourkhime Hind, Ragala Mohammed El Amine, Nejjar Fedwa, Belahsen Mohammed Faouzi
From the Laboratory of Epidemiology and Health Sciences Research, Faculty of Medicine, Pharmacy and Dentistry, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health and Quality of Life, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez, Morocco.
Int J MS Care. 2025 Jan 27;27(Q1):25-33. doi: 10.7224/1537-2073.2024-036. eCollection 2025 Jan.
The quality of life (QOL) of people with multiple sclerosis (MS) is considerably poorer than the QOL of people with other chronic diseases. QOL management should not be restricted to only clinical aspects but also factors modifying QOL. The aim of this study was to identify the sociodemographic and clinical determinants of QOL in people with MS.
A cross-sectional study conducted from 2022 to 2023 included 200 participants aged 18 and over recruited from the Hassan II University Medical Hospital in Fez, Morocco. QOL assessment was performed using the Arabic version of the Multiple Sclerosis Quality of Life-54 (MSQOL-54) questionnaire. Univariate analysis using Student test, analysis of variance, and Pearson correlation was performed, followed by multiple linear regression analysis to determine the main factors associated with QOL.
QOL was impaired in the physical health (PH) (48.51±22.08) and mental health (MH) (48.69±17.18) components of the MSQOL-54. Male sex, unemployment, and high scores on the Expanded Disability Status Scale (EDSS) were factors significantly associated with lower scores on both the PH and MH components. In contrast, later age at MS diagnosis and older age were significantly associated with worse PH and MH, respectively. EDSS score was a strong predictor of QOL (PH: β = -34.983; 95% CI, -39.64 to -30.31; MH: β = -23.383; 95% CI, -27.62 to -19.14).
The results highlight the importance of sociodemographic and clinical determinants of QOL. Clinicians need to integrate a biopsychosocial approach into therapeutic education programs, considering the risk factors and specific needs of people with MS to optimize their QOL.
多发性硬化症（MS）患者的生活质量（QOL）明显低于其他慢性病患者。生活质量管理不应仅限于临床方面，还应考虑影响生活质量的因素。本研究的目的是确定MS患者生活质量的社会人口统计学和临床决定因素。
2022年至2023年进行的一项横断面研究纳入了200名年龄在18岁及以上的参与者，他们是从摩洛哥非斯的哈桑二世大学医学医院招募的。使用阿拉伯语版的多发性硬化症生活质量-54（MSQOL-54）问卷进行生活质量评估。采用学生t检验、方差分析和Pearson相关性进行单因素分析，随后进行多元线性回归分析以确定与生活质量相关的主要因素。
MSQOL-54的身体健康（PH）（48.51±22.08）和心理健康（MH）（48.69±17.18）分量表中的生活质量受损。男性、失业以及扩展残疾状态量表（EDSS）得分高是与PH和MH分量表得分较低显著相关的因素。相比之下，MS诊断时年龄较大和年龄较大分别与较差的PH和MH显著相关。EDSS得分是生活质量的有力预测指标（PH：β = -34.983；95%CI，-39.64至-30.31；MH：β = -23.383；95%CI，-27.62至-19.14）。
结果突出了生活质量的社会人口统计学和临床决定因素的重要性。临床医生需要将生物心理社会方法纳入治疗教育计划，考虑MS患者的风险因素和特定需求，以优化他们的生活质量。
