检测和拯救停摆的核糖体。
Detecting and Rescuing Stalled Ribosomes.
机构信息
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.
出版信息
Trends Biochem Sci. 2021 Sep;46(9):731-743. doi: 10.1016/j.tibs.2021.03.008. Epub 2021 May 6.
Abstract
Ribosomes that stall inappropriately during protein synthesis harbor proteotoxic components linked to cellular stress and neurodegenerative diseases. Molecular mechanisms that rescue stalled ribosomes must selectively detect rare aberrant translational complexes and process the heterogeneous components. Ribosome-associated quality control pathways eliminate problematic messenger RNAs and nascent proteins on stalled translational complexes. In addition, recent studies have uncovered general principles of stall recognition upstream of quality control pathways and fail-safe mechanisms that ensure nascent proteome integrity. Here, we discuss developments in our mechanistic understanding of the detection and rescue of stalled ribosomal complexes in eukaryotes.
摘要
核糖体在蛋白质合成过程中不适当地停顿，携带与细胞应激和神经退行性疾病相关的蛋白毒性成分。拯救停顿核糖体的分子机制必须选择性地检测罕见的异常翻译复合物，并处理异质成分。核糖体相关的质量控制途径消除了停顿翻译复合物上有问题的信使 RNA 和新生蛋白质。此外，最近的研究揭示了质量控制途径上游的 stall 识别的一般原则和确保新生蛋白质组完整性的故障安全机制。在这里，我们讨论了我们对真核生物中停顿核糖体复合物的检测和拯救的机制理解的发展。
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