International Alliance for Biological Standardization, IABS, Geneva, Switzerland.
Vaccine R&D, Coalition for Epidemic Preparedness Innovations, CEPI, London, United Kingdom.
Biologicals. 2021 Jun;71:55-60. doi: 10.1016/j.biologicals.2021.04.005. Epub 2021 May 7.
The International Alliance for Biological Standardization and the Coalition for Epidemic Preparedness Innovations organized a joint webinar on the use of platform technologies for vaccine development. To tackle new emerging infectious diseases, including SARS-CoV-2, rapid response platforms, using the same basic components as a backbone, yet adaptable for use against different pathogens by inserting new genetic or protein sequences, are essential. Furthermore, it is evident that development of platform technologies needs to continue, due to the emerging variants of SARS-CoV-2. The objective of the meeting was to discuss techniques for platform manufacturing that have been used for COVID-19 vaccine development, with input from regulatory authorities on their experiences with, and expectations of, the platforms. Industry and regulators have been very successful in cooperating, having completed the whole process from development to licensing at an unprecedented speed. However, we should learn from the experiences, to be able to be even faster when a next pandemic of disease X occurs.
国际生物标准化联盟和流行病防范创新联盟组织了一次联合网络研讨会,主题是使用平台技术进行疫苗开发。为了应对包括 SARS-CoV-2 在内的新出现的传染病,快速反应平台至关重要,这些平台使用相同的基本组件作为骨干,但可以通过插入新的遗传或蛋白质序列来适应针对不同病原体的用途。此外,由于 SARS-CoV-2 的不断出现,显然需要继续开发平台技术。会议的目的是讨论已用于 COVID-19 疫苗开发的平台制造技术,并听取监管机构对平台的经验和期望的意见。工业界和监管机构在合作方面非常成功,以空前的速度完成了从开发到许可的整个过程。然而,我们应该从经验中吸取教训,以便在下一次疾病 X 大流行时能够更快地应对。