CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 101408, China.
J Genet Genomics. 2021 Feb 20;48(2):107-114. doi: 10.1016/j.jgg.2021.02.006. Epub 2021 Mar 15.
The ongoing COVID-19 pandemic and its unprecedented global societal and economic disruptive impact highlight the urgent need for safe and effective vaccines. Taking substantial advantages of versatility and rapid development, two mRNA vaccines against COVID-19 have completed late-stage clinical assessment at an unprecedented speed and reported positive results. In this review, we outline keynotes in mRNA vaccine development, discuss recently published data on COVID-19 mRNA vaccine candidates, focusing on those in clinical trials and analyze future potential challenges.
持续的 COVID-19 大流行及其前所未有的全球社会和经济破坏性影响凸显了安全有效的疫苗的迫切需求。得益于多功能性和快速发展的巨大优势，两种针对 COVID-19 的 mRNA 疫苗以空前的速度完成了后期临床评估，并报告了积极的结果。在这篇综述中，我们概述了 mRNA 疫苗开发的要点，讨论了最近关于 COVID-19 mRNA 疫苗候选物的发表数据，重点是那些正在临床试验中的，并分析了未来的潜在挑战。
