Department of Cardiac Electrophysiology, Affiliated Hospital of Chengde Medical College, Chengde Hebei 067000.
Department of Endocrinology, Affiliated Hospital of Chengde Medical College, Chengde Hebei 067000, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Apr 28;46(4):373-378. doi: 10.11817/j.issn.1672-7347.2021.200222.
To investigate the level and significance of serum γ-glutamyl transferase-to-platelet ratio (GPR) and monocyte count to high-density lipoprotein ratio (MHR) in patients with essential hypertension (EH) and unstable angina (UA).
A total of 218 patients with coronary angiography aged ≥60 years, who were admitted to the EH hospital of the Department of Cardiac Medicine, Affiliated Hospital of Chengde Medical College, were selected from September 2018 to September 2019. They were divided into an EH+UA group (=113) and an EH group (=105). In addition, 106 patients with normal coronary angiography who were diagnosed with coronary heart disease were selected as a control group. The general data, blood biochemical indicators, GPR and MHR in each group were compared, and partial correlation analysis and receiver operator characteristic (ROC) curve analysis were performed.
Compared with the control group, patients in the EH+UA group and the EH group had higher body mass index (BMI), tyiglyceride (TG), GPR, and MHR, and lower high-density lipoprotein-cholesterol (HDL-C) (all <0.05); and patients in the EH+UA group had higher white blood cell counts, alanine aminotransferase (ALT), and uric acid (all <0.05). Compared with the EH group, patients in the EH+UA group had higher GPR and MHR (both <0.05). Partial correlation analysis showed that after controlling the antihypertensive drugs and lipid-lowering drugs, GPR was found to be positively correlated with BMI, white blood cell count, ALT, TG, and uric acid (=0.160, 0.111, 0.205, 0.250, 0.154, respectively, all <0.05), which was negatively correlated with HDL-C (=-0.238, <0.05); MHR was positively correlated with BMI, ALT, TG, uric acid, and GPR (=0.186, 0.307, 0.157, 0.141, 0.223, respectively, all <0.05), and negatively correlated with HDL-C (=-0.610, <0.001). ROC curve analysis showed that GPR had higher specificity and positive predictive value, while MHR had higher sensitivity. When the two indicators were combined, the sensitivity and positive predictive value were higher.
There is a correlation between GPR, MHR and EH combined with UA pectoris, and the combined detection of the two indicators has adjuvant diagnostic value for elderly EH combined with UA.
探讨血清γ-谷氨酰转移酶/血小板比值（GPR）和单核细胞/高密度脂蛋白比值（MHR）在原发性高血压（EH）合并不稳定型心绞痛（UA）患者中的水平及意义。
选取 2018 年 9 月至 2019 年 9 月在承德医学院附属医院心脏医学科 EH 病房住院并行冠状动脉造影检查的年龄≥60 岁的患者 218 例，分为 EH+UA 组（n=113）和 EH 组（n=105）。另选取同期在我院行冠状动脉造影检查诊断为冠心病且冠状动脉正常的患者 106 例作为对照组。比较各组一般资料、血生化指标、GPR 和 MHR，行相关性分析和受试者工作特征（ROC）曲线分析。
与对照组比较，EH+UA 组和 EH 组患者体质量指数（BMI）、甘油三酯（TG）、GPR 和 MHR 均升高，高密度脂蛋白胆固醇（HDL-C）均降低（均<0.05）；白细胞计数、丙氨酸氨基转移酶（ALT）和尿酸均升高（均<0.05）。与 EH 组比较，EH+UA 组 GPR 和 MHR 均升高（均<0.05）。相关性分析显示，校正降压药和降脂药后，GPR 与 BMI、白细胞计数、ALT、TG、尿酸呈正相关（r=0.160、0.111、0.205、0.250、0.154，均<0.05），与 HDL-C 呈负相关（r=-0.238，<0.05）；MHR 与 BMI、ALT、TG、尿酸、GPR 呈正相关（r=0.186、0.307、0.157、0.141、0.223，均<0.05），与 HDL-C 呈负相关（r=-0.610，<0.001）。ROC 曲线分析显示，GPR 具有较高的特异性和阳性预测值，MHR 具有较高的灵敏度，两者联合检测时，灵敏度和阳性预测值更高。
GPR、MHR 与 EH 合并 UA 有相关性，联合检测两项指标对老年 EH 合并 UA 有辅助诊断价值。
