抗线粒体抗体 2 型相关肌炎伴复视和上睑下垂。

Myositis with Anti-mitochondrial Antibody Type 2 with Diplopia and Ptosis.

机构信息

Department of Neurology, Kushiro Rosai Hospital, Japan.

Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.

出版信息

Intern Med. 2021 Oct 15;60(20):3325-3328. doi: 10.2169/internalmedicine.7031-21. Epub 2021 May 7.

DOI:10.2169/internalmedicine.7031-21

PMID:33967136

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8580766/

Abstract

Anti-mitochondrial antibody type 2 is a diagnostic marker of primary biliary cirrhosis and complicates myositis. Myositis with anti-mitochondrial antibody type 2 is clinically characterized by slowly progressive limb, cardiac, and respiratory muscle weakness as well as serum creatinine kinase elevations. However, there has been few cases with eye symptoms. We herein report a 59-year-old woman with anti-mitochondrial antibody type 2 who presented with diplopia and ptosis. Magnetic resonance imaging revealed bilateral ocular muscle enlargement and abnormally high intensities in the lower limb muscles. Corticosteroid therapy improved these symptoms. Myositis with anti-mitochondrial antibody type 2 can present with eye symptoms.

摘要

抗线粒体抗体 2 型是原发性胆汁性肝硬化的诊断标志物，并使多发性肌炎复杂化。抗线粒体抗体 2 型相关的多发性肌炎临床上以进行性四肢、心脏和呼吸肌无力以及血清肌酸激酶升高为特征。然而，眼部症状较为少见。本文报道了一例 59 岁女性，以复视和眼睑下垂为表现，伴抗线粒体抗体 2 型阳性。磁共振成像显示双侧眼外肌增大，下肢肌肉信号异常增高。皮质类固醇治疗改善了这些症状。抗线粒体抗体 2 型相关的多发性肌炎可出现眼部症状。