• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

雌激素受体缺失会延缓肌肉再生，并在低雌激素状态下导致肌间脂肪生成：雌激素受体α和β基因敲除小鼠的形态学比较

Absence of estrogen receptors delays myoregeneration and leads to intermuscular adipogenesis in a low estrogen status: Morphological comparisons in estrogen receptor alpha and beta knock out mice.

作者信息

Chaiyasing Rattanatrai, Ishikawa Takuro, Warita Katsuhiko, Hosaka Yoshinao Z

机构信息

Laboratory of Basic Veterinary Science, United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan.

Faculty of Veterinary Sciences, Office of Academic Affairs, Maha Sarakham University, Maha Sarakham 44000, Thailand.

出版信息

J Vet Med Sci. 2021 Jul 2;83(7):1022-1030. doi: 10.1292/jvms.20-0696. Epub 2021 May 10.

DOI:10.1292/jvms.20-0696
PMID:33967186
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8349812/
Abstract

This study aimed to investigate the function of estrogen receptors (ERs) in myoregeneration and intermuscular adipogenesis. Ovariectomized (OVX) ERα knockout (KO) mice and ERβ KO mice were used to assess the effect of estrogen on the myoregenerative process. Tibialis anterior muscle was collected on days 7, 10, and 14 after cardiotoxin injection to assess myotube morphology and adipogenesis area. Regenerated myotubes from OVX-ERβ KO mice were consistently smaller in diameter than those from OVX-ERα KO and OVX-wild-type mice, whereas the adipogenesis area of OVX-ERβ KO mice was consistently greater than that of the other types. Therefore, ERβ may be an influential factor in promoting myoregeneration and adipogenesis inhibition compared to ERα.

摘要

本研究旨在探讨雌激素受体（ERs）在肌肉再生和肌间脂肪生成中的作用。采用卵巢切除（OVX）的ERα基因敲除（KO）小鼠和ERβ基因敲除小鼠来评估雌激素对肌肉再生过程的影响。在注射心脏毒素后第7、10和14天采集胫骨前肌，以评估肌管形态和脂肪生成面积。OVX-ERβ基因敲除小鼠再生的肌管直径始终小于OVX-ERα基因敲除小鼠和OVX野生型小鼠，而OVX-ERβ基因敲除小鼠的脂肪生成面积始终大于其他类型小鼠。因此，与ERα相比，ERβ可能是促进肌肉再生和抑制脂肪生成的一个影响因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/075e/8349812/64ff6e17c941/jvms-83-1022-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/075e/8349812/6acf1ddb3cb8/jvms-83-1022-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/075e/8349812/ac9fdaa8c6c4/jvms-83-1022-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/075e/8349812/4d7cfd27ac8e/jvms-83-1022-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/075e/8349812/64ff6e17c941/jvms-83-1022-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/075e/8349812/6acf1ddb3cb8/jvms-83-1022-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/075e/8349812/ac9fdaa8c6c4/jvms-83-1022-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/075e/8349812/4d7cfd27ac8e/jvms-83-1022-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/075e/8349812/64ff6e17c941/jvms-83-1022-g004.jpg

相似文献

1
Absence of estrogen receptors delays myoregeneration and leads to intermuscular adipogenesis in a low estrogen status: Morphological comparisons in estrogen receptor alpha and beta knock out mice.雌激素受体缺失会延缓肌肉再生，并在低雌激素状态下导致肌间脂肪生成：雌激素受体α和β基因敲除小鼠的形态学比较
J Vet Med Sci. 2021 Jul 2;83(7):1022-1030. doi: 10.1292/jvms.20-0696. Epub 2021 May 10.
2
Estrogen modulates the skeletal muscle regeneration process and myotube morphogenesis: morphological analysis in mice with a low estrogen status.雌激素调节骨骼肌再生过程和肌管形态发生：低雌激素状态小鼠的形态学分析。
J Vet Med Sci. 2021 Dec 2;83(12):1812-1819. doi: 10.1292/jvms.21-0495. Epub 2021 Oct 19.
3
Estrogen receptor α- (ERα), but not ERβ-signaling, is crucially involved in mechanostimulation of bone fracture healing by whole-body vibration.雌激素受体 α（ERα），而不是 ERβ 信号，在全身振动机械刺激骨愈合中起着至关重要的作用。
Bone. 2018 May;110:11-20. doi: 10.1016/j.bone.2018.01.017. Epub 2018 Feb 3.
4
Effects of ERβ and ERα on OVX-induced changes in adiposity and insulin resistance.ERβ 和 ERα 对去卵巢诱导的肥胖和胰岛素抵抗变化的影响。
J Endocrinol. 2020 Apr;245(1):165-178. doi: 10.1530/JOE-19-0321.
5
Adaptation of arcuate insulin receptor, estrogen receptor-alpha, estrogen receptor-beta, and type-II glucocorticoid receptor gene profiles to chronic intermediate insulin-induced hypoglycemia in estrogen-treated ovariectomized female rats.弓形胰岛素受体、雌激素受体-α、雌激素受体-β和 II 型糖皮质激素受体基因谱对雌激素处理去卵巢雌性大鼠慢性中等胰岛素诱导低血糖的适应。
J Mol Neurosci. 2010 Jun;41(2):304-9. doi: 10.1007/s12031-009-9314-4. Epub 2009 Dec 2.
6
Estrogen receptor α in mature osteoblasts regulates the late stage of bone regeneration.成熟成骨细胞中的雌激素受体α 调节骨再生的晚期阶段。
Biochem Biophys Res Commun. 2021 Jun 25;559:238-244. doi: 10.1016/j.bbrc.2021.04.112. Epub 2021 May 5.
7
Rat uterine oxytocin receptor and estrogen receptor α and β mRNA levels are regulated by estrogen through multiple estrogen receptors.大鼠子宫催产素受体以及雌激素受体α和β的mRNA水平受雌激素通过多种雌激素受体调控。
J Reprod Dev. 2014 Mar 7;60(1):55-61. doi: 10.1262/jrd.2012-139. Epub 2013 Dec 16.
8
Selective estrogen receptor-β activation stimulates skeletal muscle growth and regeneration.选择性雌激素受体-β 激活可刺激骨骼肌生长和再生。
FASEB J. 2012 May;26(5):1909-20. doi: 10.1096/fj.11-194779. Epub 2012 Jan 25.
9
Estrogen receptor-alpha and -beta and aromatase knockout effects on lower limb muscle mass and contractile function in female mice.雌激素受体α和β以及芳香化酶基因敲除对雌性小鼠下肢肌肉质量和收缩功能的影响。
Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E854-61. doi: 10.1152/ajpendo.90696.2008. Epub 2009 Jan 27.
10
Endogenous estrogen receptor beta is transcriptionally active in primary ovarian cells from estrogen receptor knockout mice.内源性雌激素受体β在雌激素受体基因敲除小鼠的原代卵巢细胞中具有转录活性。
Steroids. 2004 Sep;69(10):681-6. doi: 10.1016/j.steroids.2004.06.004.

引用本文的文献

1
Reduced myogenic differentiation capacity of satellite cell-derived myoblasts in male ICR mice compared with male C57BL/6 and BALB/c mice.与雄性C57BL/6和BALB/c小鼠相比，雄性ICR小鼠中卫星细胞衍生的成肌细胞的成肌分化能力降低。
In Vitro Cell Dev Biol Anim. 2025 May 19. doi: 10.1007/s11626-025-01035-0.
2
Depot-specific adiposity changes in ovariectomized mice on high-fat diet.高脂饮食下卵巢切除小鼠特定部位脂肪的变化
J Vet Med Sci. 2025 Mar 1;87(3):241-247. doi: 10.1292/jvms.24-0442. Epub 2025 Jan 22.
3
Roles of Estrogen, Estrogen Receptors, and Estrogen-Related Receptors in Skeletal Muscle: Regulation of Mitochondrial Function.

本文引用的文献

1
Estrogen Receptor β Controls Muscle Growth and Regeneration in Young Female Mice.雌激素受体β调控年轻雌性小鼠的肌肉生长与再生。
Stem Cell Reports. 2020 Sep 8;15(3):577-586. doi: 10.1016/j.stemcr.2020.07.017. Epub 2020 Aug 20.
2
The crosstalk between IGF-1R and ER-α in the proliferation and anti-inflammation of nucleus pulposus cells.IGF-1R 与 ER-α 在椎间盘细胞增殖和抗炎中的相互作用。
Eur Rev Med Pharmacol Sci. 2020 Jun;24(11):5886-5894. doi: 10.26355/eurrev_202006_21481.
3
Mechanisms Regulating Muscle Regeneration: Insights into the Interrelated and Time-Dependent Phases of Tissue Healing.
雌激素、雌激素受体和雌激素相关受体在骨骼肌中的作用：调节线粒体功能。
Int J Mol Sci. 2023 Jan 17;24(3):1853. doi: 10.3390/ijms24031853.
4
Estrogen modulates the skeletal muscle regeneration process and myotube morphogenesis: morphological analysis in mice with a low estrogen status.雌激素调节骨骼肌再生过程和肌管形态发生：低雌激素状态小鼠的形态学分析。
J Vet Med Sci. 2021 Dec 2;83(12):1812-1819. doi: 10.1292/jvms.21-0495. Epub 2021 Oct 19.
调控肌肉再生的机制：组织愈合的相互关联和时相关阶段的深入了解。
Cells. 2020 May 22;9(5):1297. doi: 10.3390/cells9051297.
4
Estrogen Regulates the Satellite Cell Compartment in Females.雌激素调控雌性个体卫星细胞隔室。
Cell Rep. 2019 Jul 9;28(2):368-381.e6. doi: 10.1016/j.celrep.2019.06.025.
5
Functions of estrogen and estrogen receptor signaling on skeletal muscle.雌激素和雌激素受体信号对骨骼肌的作用。
J Steroid Biochem Mol Biol. 2019 Jul;191:105375. doi: 10.1016/j.jsbmb.2019.105375. Epub 2019 May 5.
6
The Release of Adipose Stromal Cells from Subcutaneous Adipose Tissue Regulates Ectopic Intramuscular Adipocyte Deposition.脂肪基质细胞从皮下脂肪组织的释放调节异位肌内脂肪细胞的沉积。
Cell Rep. 2019 Apr 9;27(2):323-333.e5. doi: 10.1016/j.celrep.2019.03.038.
7
Adipocytes suppress differentiation of muscle cells in a co-culture system.在共培养系统中，脂肪细胞会抑制肌肉细胞的分化。
Anim Sci J. 2019 Mar;90(3):423-434. doi: 10.1111/asj.13145. Epub 2018 Dec 25.
8
Estrogen signaling increases nuclear receptor subfamily 4 group A member 1 expression and energy production in skeletal muscle cells.雌激素信号传导增加骨骼肌细胞中核受体亚家族4 A组成员1的表达及能量产生。
Endocr J. 2018 Dec 28;65(12):1209-1218. doi: 10.1507/endocrj.EJ17-0548. Epub 2018 Oct 17.
9
Compensatory role of insulin-like growth factor 1 receptor in estrogen receptor signaling pathway and possible therapeutic target for hormone therapy-resistant breast cancer.胰岛素样生长因子 1 受体在雌激素受体信号通路中的代偿作用及其成为激素治疗抵抗性乳腺癌的可能治疗靶点。
Breast Cancer. 2019 May;26(3):272-281. doi: 10.1007/s12282-018-0922-0. Epub 2018 Oct 16.
10
The function of myostatin in the regulation of fat mass in mammals.肌肉生长抑制素在哺乳动物脂肪量调节中的作用。
Nutr Metab (Lond). 2017 Mar 21;14:29. doi: 10.1186/s12986-017-0179-1. eCollection 2017.