Kim Seung Han, Kim Hong Bae, Chun Hoon Jai, Choi Hyuk Soon, Kim Eun Sun, Keum Bora, Seo Yeon Seok, Jeen Yoon Tae, Lee Hong Sik, Um Soon Ho, Kim Chang Duck
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Institute of Gastrointestinal Medical Instrument Research, Korea University College of Medicine, Seoul, Korea.
Department of Biosystems and Biomaterials Science and Engineering, Seoul National University, Seoul, Korea.
J Neurogastroenterol Motil. 2020 Jul 30;26(3):410-416. doi: 10.5056/jnm20063.
BACKGROUND/AIMS: Gastric electrical stimulation (GES) is a feasible modality for the treatment of gastroparesis; however, the presently available device requires invasive surgical implantation for long-term stimulation and repeated surgical procedure after a period of time. This study is aimed at developing a wireless miniature GES device and testing its endoscopic insertion in animal models.
Endoscopic gastric implantation of the GES device was performed on 5 healthy weaner pigs under general anesthesia. We created an endoscopic submucosal pocket and inserted the gastro-electrical stimulator. In vivo gastric slow waves were recorded and measured during electrical stimulation. A multi-channel recorder, called an electrogastrogram, was used to record the gastric myoelectrical activity in the study.
The gastric slow waves on the electrogastrogram were more consistent with GES on the gastric tissues compared to no stimulation. The frequency-to-amplitude ratio was also significantly altered after the electrical stimulation.
GES is feasible with our minimally invasive wireless device. This technique has the potential to increase utilization of GES as a treatment alternative.
背景/目的：胃电刺激（GES）是治疗胃轻瘫的一种可行方法；然而，目前可用的设备需要通过侵入性手术植入来进行长期刺激，且一段时间后需要重复手术。本研究旨在开发一种无线微型GES设备，并在动物模型中测试其内镜下植入情况。
在全身麻醉下，对5只健康断奶仔猪进行GES设备的内镜下胃植入。我们创建了一个内镜下黏膜下口袋并插入胃电刺激器。在电刺激期间记录并测量体内胃慢波。在本研究中，使用一种称为胃电图仪的多通道记录仪来记录胃肌电活动。
与无刺激相比，胃电图上的胃慢波与胃组织上的GES更一致。电刺激后频率与振幅比也有显著改变。
使用我们的微创无线设备进行GES是可行的。该技术有可能增加GES作为一种治疗选择的应用。
