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Andrographolide Against Lung Cancer-New Pharmacological Insights Based on High-Throughput Metabolomics Analysis Combined with Network Pharmacology.

作者信息

Luo Wen, Jia Li, Zhang Jia-Wen, Wang Dong-Jie, Ren Qiu, Zhang Wei

机构信息

Respiratory Department, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, China.

Department of Respiratory and Critical Care, First Affiliated Hospital, Harbin Medical University, Harbin, China.

出版信息

Front Pharmacol. 2021 Apr 21;12:596652. doi: 10.3389/fphar.2021.596652. eCollection 2021.

DOI:10.3389/fphar.2021.596652
PMID:33967748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8097142/
Abstract

Andrographolide (Andro) has known to treat various illnesses such as colds, diarrhea, fever and infectious diseases. However, the effect mechanism of Andro is still unclear. Therefore, we used high-throughput metabolomics analysis to discover biomarkers, metabolic profiles and pathways to reveal the pharmacological action and effective mechanism of Andro against lung cancer. The metabolic effects of Andro on lung cancer animal was explored by ultra-performance liquid chromatography-triple-time of flight/mass spectrometry (UPLC-TOF/MS) analysis. Our results showed that Andro exhibited significant protective effects against lung cancer. Compared with control group, a total of 25 metabolites biomarkers was identified in urine of model animals, which 18 of them were regulated toward the normal direction after Andro treatment, and network pharmacology analysis showed that they were related with 570 proteins. Biological pathways analysis showed that the 11 metabolism pathways were regulated by Andro treatment in lung cancer mouse, and amino acid metabolism and arachidonic acid metabolism have great potential as target pathways for Andro against lung cancer. It revealed that high-throughput metabolomics combined with network pharmacology analysis provides deeply insight into the therapeutic mechanisms of natural product for promoting medicine development and disease treatment.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94be/8097142/cdc733e31652/fphar-12-596652-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94be/8097142/0594335cff5b/fphar-12-596652-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94be/8097142/0ce1f4925a9a/fphar-12-596652-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94be/8097142/50dc674cc036/fphar-12-596652-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94be/8097142/bffbe2638baf/fphar-12-596652-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94be/8097142/ed059c3f64b7/fphar-12-596652-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94be/8097142/9551d73e2082/fphar-12-596652-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94be/8097142/df179345d52a/fphar-12-596652-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94be/8097142/cdc733e31652/fphar-12-596652-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94be/8097142/0594335cff5b/fphar-12-596652-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94be/8097142/0ce1f4925a9a/fphar-12-596652-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94be/8097142/50dc674cc036/fphar-12-596652-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94be/8097142/bffbe2638baf/fphar-12-596652-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94be/8097142/ed059c3f64b7/fphar-12-596652-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94be/8097142/9551d73e2082/fphar-12-596652-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94be/8097142/df179345d52a/fphar-12-596652-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94be/8097142/cdc733e31652/fphar-12-596652-g008.jpg

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引用本文的文献

[1]
Andrographolide induces protective autophagy and targeting DJ-1 triggers reactive oxygen species-induced cell death in pancreatic cancer.

PeerJ. 2024

[2]
An Integrated Network Pharmacology and RNA-seq Approach for Exploring the Protective Effect of Andrographolide in Doxorubicin-Induced Cardiotoxicity.

Cardiovasc Drugs Ther. 2024-2-24

[3]
Anti-Cancer Agent: The Labdane Diterpenoid-Andrographolide.

Plants (Basel). 2023-5-12

[4]
Targeting Inflammation in Non-Small Cell Lung Cancer through Drug Repurposing.

Pharmaceuticals (Basel). 2023-3-16

[5]
Probing Folate-Responsive and Stage-Sensitive Metabolomics and Transcriptional Co-Expression Network Markers to Predict Prognosis of Non-Small Cell Lung Cancer Patients.

Nutrients. 2022-12-20

[6]
AZGP1 Up-Regulation is a Potential Target for Andrographolide Reversing Radioresistance of Colorectal Cancer.

Pharmgenomics Pers Med. 2022-12-13

本文引用的文献

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Metabolomic estimation of the diagnosis of hepatocellular carcinoma based on ultrahigh performance liquid chromatography coupled with time-of-flight mass spectrometry.

RSC Adv. 2018-3-6

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Mol Med Rep. 2019-9-2

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Oncol Lett. 2019-8

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