支链氨基酸代谢在癌症中的新兴作用。
Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer.
机构信息
Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02215, USA.
出版信息
Cancer Cell. 2020 Feb 10;37(2):147-156. doi: 10.1016/j.ccell.2019.12.011.
Abstract
Metabolic pathways must be adapted to support cell processes required for transformation and cancer progression. Amino acid metabolism is deregulated in many cancers, with changes in branched-chain amino acid metabolism specifically affecting cancer cell state as well as systemic metabolism in individuals with malignancy. This review highlights key concepts surrounding the current understanding of branched-chain amino acid metabolism and its role in cancer.
摘要
代谢途径必须适应以支持转化和癌症进展所需的细胞过程。许多癌症中氨基酸代谢失调，支链氨基酸代谢的变化特别影响癌症细胞状态以及恶性肿瘤个体的全身代谢。这篇综述强调了当前对支链氨基酸代谢及其在癌症中的作用的理解的关键概念。
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